ID A0A077FNI7_9RICK Unreviewed; 393 AA.
AC A0A077FNI7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:AIL65534.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:AIL65534.1};
GN Name=phbA {ECO:0000313|EMBL:AIL65534.1};
GN ORFNames=NOVO_05870 {ECO:0000313|EMBL:AIL65534.1};
OS Rickettsiales bacterium Ac37b.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales.
OX NCBI_TaxID=1528098 {ECO:0000313|EMBL:AIL65534.1, ECO:0000313|Proteomes:UP000028936};
RN [1] {ECO:0000313|EMBL:AIL65534.1, ECO:0000313|Proteomes:UP000028936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac37b {ECO:0000313|EMBL:AIL65534.1,
RC ECO:0000313|Proteomes:UP000028936};
RA Felsheim R.F., Kurtti T.J., Johnson S., Labruna M.B., Munderloh U.G.;
RT "Genome sequence of a novel Rickettsiales species cultured from Amblyomma
RT cajennense.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP009217; AIL65534.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077FNI7; -.
DR STRING; 1528098.NOVO_05870; -.
DR KEGG; rbt:NOVO_05870; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_0_0_5; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000028936; Chromosome.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:AIL65534.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028936};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:AIL65534.1}.
FT DOMAIN 6..262
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 271..391
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 349
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 379
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 393 AA; 41714 MW; 0DF6DF312895815E CRC64;
MQTREVVIVD AVRTPIGNLN GAFISIAAHK LGEIVIRALL DRNNVDANMI SEVMMGQVLT
GACGQNPARQ ASMNSGIPNN IPAFTINKVC GSGLKAVMLA AQSIMLGEND IVIAGGQESM
TMTSHAAYVR TGVRMGDTNL VDMMIKDGLI DAFNNYHMGI TAENVAKKYD ISRSKQDEFS
CNSQNKAESA QKSGKFVDEI IPVKIQSKKG EVIVEQDEFI KHGTTVEILS KLRPAFDKNG
TVTAGNASGI NDGAAALLLM SAELAKKLGK KPLVSIKSWG KSGVDPAIMG IAPIYAVEKA
LKNASWQHTQ LDLIEANEAF ASQSIAIDQE IGWDITKVNV NGGAIALGHP IGASGARILV
TLLHEMKRRS VRKGIATLCI GGGMGVAMCV EAK
//
