ID A0A077RQR9_WHEAT Unreviewed; 303 AA.
AC A0A077RQR9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=hydroxyethylthiazole kinase {ECO:0000256|ARBA:ARBA00012129};
DE EC=2.7.1.50 {ECO:0000256|ARBA:ARBA00012129};
GN ORFNames=CFC21_044033 {ECO:0000313|EMBL:KAF7032901.1},
GN TRAES_3BF015600010CFD_c1 {ECO:0000313|EMBL:CDM81919.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EMBL:CDM81919.1};
RN [1] {ECO:0000313|EMBL:CDM81919.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25035497; DOI=10.1126/science.1249721;
RA Choulet F., Alberti A., Theil S., Glover N., Barbe V., Daron J.,
RA Pingault L., Sourdille P., Couloux A., Paux E., Leroy P., Mangenot S.,
RA Guilhot N., Le Gouis J., Balfourier F., Alaux M., Jamilloux V., Poulain J.,
RA Durand C., Bellec A., Gaspin C., Safar J., Dolezel J., Rogers J.,
RA Vandepoele K., Aury J.M., Mayer K., Berges H., Quesneville H., Wincker P.,
RA Feuillet C.;
RT "Structural and functional partitioning of bread wheat chromosome 3B.";
RL Science 345:1249721-1249721(2014).
RN [2] {ECO:0000313|EMBL:KAF7032901.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7032901.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3B02G510900.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3B02G510900.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [4] {ECO:0000313|EnsemblPlants:TraesCS3B02G510900.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [5] {ECO:0000313|EMBL:KAF7032901.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7032901.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-
CC phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=2.7.1.50;
CC Evidence={ECO:0000256|ARBA:ARBA00001771};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-
CC methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-
CC methylthiazole: step 1/1. {ECO:0000256|ARBA:ARBA00004868}.
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DR EMBL; HG670306; CDM81919.1; -; Genomic_DNA.
DR EMBL; CM022218; KAF7032901.1; -; Genomic_DNA.
DR SMR; A0A077RQR9; -.
DR STRING; 4565.A0A077RQR9; -.
DR PaxDb; 4565-Traes_3B_A510D66CC-1; -.
DR EnsemblPlants; TraesCS3B02G510900.1; TraesCS3B02G510900.1; TraesCS3B02G510900.
DR Gramene; TraesCS3B02G510900.1; TraesCS3B02G510900.1; TraesCS3B02G510900.
DR Gramene; TraesPAR_scaffold_041164_01G000200.1; TraesPAR_scaffold_041164_01G000200.1; TraesPAR_scaffold_041164_01G000200.
DR Gramene; TraesROB_scaffold_014065_01G000200.1; TraesROB_scaffold_014065_01G000200.1; TraesROB_scaffold_014065_01G000200.
DR Gramene; TraesWEE_scaffold_063615_01G000200.1; TraesWEE_scaffold_063615_01G000200.1; TraesWEE_scaffold_063615_01G000200.
DR HOGENOM; CLU_019943_0_1_1; -.
DR OMA; FRMESCL; -.
DR UniPathway; UPA00060; UER00139.
DR Proteomes; UP000019116; Chromosome 3B.
DR Proteomes; UP000815260; Chromosome 3B.
DR ExpressionAtlas; A0A077RQR9; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004417; F:hydroxyethylthiazole kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01170; THZ_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR HAMAP; MF_00228; Thz_kinase; 1.
DR InterPro; IPR000417; Hyethyz_kinase.
DR InterPro; IPR029056; Ribokinase-like.
DR Pfam; PF02110; HK; 2.
DR PIRSF; PIRSF000513; Thz_kinase; 2.
DR PRINTS; PR01099; HYETHTZKNASE.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977}.
FT REGION 135..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 303 AA; 31387 MW; 8AB7EE75BCAEE710 CRC64;
MDDERTEAWW ARRAWALLSA VRERSPLVQR ITNLVSMDIA ANALTAAGAS PAMLHCLREI
PDFTPRCDAV YINVGTLSED WLPSMRAAAS AGRPWVLDPV AAAASGFRME SCLELLVLRP
AVVRGNASEI LALAVGNPSP PPGLPPPFPL PRRRRRGSPE RRAAAGDGGG EDLGVDSSHD
SGEALQAAKV LAQSSGAVIA VSGALDFITD GEQVISASNA VAMMQKITAT GCAVTALIAA
FVGADPSDAL DAAACALAIF GLAGEIGMES AKGPASLRMH LIDALYGLDE QTVTSGVKIA
LVL
//
