ID A0A077YZI9_TRITR Unreviewed; 886 AA.
AC A0A077YZI9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Sodium:calcium exchanger 1 {ECO:0000313|EMBL:CDW53159.1};
GN ORFNames=TTRE_0000142201 {ECO:0000313|EMBL:CDW53159.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW53159.1};
RN [1] {ECO:0000313|EMBL:CDW53159.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW53159.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR EMBL; HG805843; CDW53159.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077YZI9; -.
DR STRING; 36087.A0A077YZI9; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR11878:SF76; NA_CA EXCHANGERS; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 3.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 33..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 858..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 356..455
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 474..600
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 886 AA; 97854 MW; 14EFE7DEEA2EE68E CRC64;
MNSNVTAKFD QCSTDGLILP LVDESGWSEG TRAVLYFVGL LYSFVGVAIL ADAFMCSIER
ITSTKKRIKM QTTVDDETGS ILEHYQETII WNPTVANLTL MALGSSAPEI LLSIIEIIGN
GFKAGDLGPG TIVGSAAFNL FAITAVCIVS VPAGTKKRIE NFGVFCVTSA WSLFAYIWLI
IILIGISPNQ VEVWEGVLTL LFFVALVVNA YMTSAKMKIC RSGKRDDATR ETVQPTIVAK
NAKDLEVASS EKKRYSWLPK FADDSSQALL PDNDAKVDRL VHDMRRKYPY LSDERLTDLV
TDQITKDQGR DRLWYRIMSI RGMTSALRKK RQPPIRAEHM IQQMETMSRT GALRRTLTDT
GVRAVSNFEF AATIYAVNPL VENKVYLKVI RRGSARKQLV FTYRTVAGTA QRNAHFLPKS
ETVVMQPSER EKRICVEVCN VEKWQQQMGF WVKLELGPNT EEDDRTTLGL ASTAKIIYPE
SSNEMSIQFV HRHEQVKESE GFVRIPLVRH GLISGGIQDR SIMTVSRVVF FKSQPPSLHL
KVGCTVQWKT ENGSAKRGED YIGEGGSLVL EPGVIEAYID IPIVNDYEPE KDETFTVTLL
SCTAGSIGSN RVVVVTILND DQINRQEPYP YLADFSASKY SLGITQNSYP KQRLAAARLD
ASTWREQMLR AVSVNGGEIA EATIPDCLAH IIAFPWKVLV ALVPPPPLFN GWLTFFVSLF
LIGLLTAIVG DLASIFGCLV GLKASVTAIT FVALGTSLPD TFASKLAAQQ DRTADNAIGN
VTGSNSVNVF LGLGLPWFIA SVYWASKGKA FVVPSGDLGF SVTLFTILSL FCLVVIFLRR
SLASFGQAEL GGPILTKWAS ALLLFLFWVI YIFVSSLHTY GHISGF
//
