GenomeNet

Database: UniProt
Entry: A0A077Z4L8_TRITR
LinkDB: A0A077Z4L8_TRITR
Original site: A0A077Z4L8_TRITR 
ID   A0A077Z4L8_TRITR        Unreviewed;      1195 AA.
AC   A0A077Z4L8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=TTRE_0000189501 {ECO:0000313|EMBL:CDW53630.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW53630.1};
RN   [1] {ECO:0000313|EMBL:CDW53630.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Aslett M.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW53630.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate host-
RT   pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HG805861; CDW53630.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077Z4L8; -.
DR   STRING; 36087.A0A077Z4L8; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00358; DSRM; 2.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS50137; DS_RBD; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          3..71
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          147..220
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          364..532
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          610..806
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          112..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1195 AA;  133546 MW;  C07D5A58083F11A5 CRC64;
     MAEVKAILNQ WAAKRSIKPQ YDMRAVLGDN GLQFHCDLTL TGFDHVSYGC STNKKAAMTT
     AARDFCAFLL RTKNMDISMF PANIREDIEA DSSSSAAPNT TTTSTELVAN ISEVPKEPAS
     TDSPVGANSS KKTTDIQEDC GGWTLENSKQ CLNQFMQTYK LTNFAYEYKL SGPSHRLEFV
     AEASLPVPDL NMTISASGKG FSKKQASACC AMSLVHQLYN LGVIRKFEEA TPKKKLEVPI
     YDVFVPPPLE QDISDYLTTE GINYVEATSG SLESVSLITE DNDDSSMPVV DHLVNSVRWS
     PPIMNFNPWT GKQIEDGNWS TMTLEQISAY LFAQRFSRET SESYKLMLKA RNELPVFSSK
     EKILDAVNNN SATLVVGETG CGKTTQVCQY ILDSMLDNGK GACCNIIVTQ PRRISAITVA
     ERVATERGEK LGQSVGYSVR FDSHFPSPYG SIMFCTPFKG VLLRRMENGL QGVSHIIVDE
     VHERDVDTDF LLIILRDLLA IYPDLRVILM SATVDTSLFE QYFNGCATVH IEGRLFSVTR
     YFLEDAVQMT NFVIDEAMED SFVEDKIISE SANVENLNLI VSDSYPESVR KTVAMMPEND
     SNFELIQAII VQQIAQGVKG SILVFLPGWN IIITLQRFLE TRLADGSLTY ASYLGGIKCV
     LLPLHSQLPK ENQFQVFEAV PPGFTKVCAH FCLQLFQCHP RILLQIILAT NIAESSVTIS
     DVVMVIDSCK VKLKKYTSYN NMIHYVTTWA SKSNLQQRCG RAGRCQPGVC FHLCSKARFE
     RLDQYSEPEM LRSPLHETVL AVKLLGLGSS VNFLSKAMQP PPLDSVCEAE MVLRDIGALT
     KDSQLTALGR ILAHLPIDPV FGKTIVLGTI FSIGDIMCSI AALSSFIEPY IIPLHQKRLS
     ESQKAFTGSR FSDHTALLEI YQCFVAARHN IIISAPFNYG IQSEKDFCRS YRVNAPLLRT
     IFEATHQLKT LLQNFGFLPE LLQMHRICTR LGLIETTLLG KRCPMMALFQ MTSLLIAAYY
     PNVCWHYGKR RVLTLENTTA LIHKHSVNCE SQNVQFPSPF FVFSEKMRTG TVACRQLSMV
     THLQLLLFGA KSVELCDDLV VLDNWLKLRM SPVVAAKIVA LRRCVNRLVG LAKCHLTNEK
     ECGDELQNVQ DSTCRAVAAE EGIVMVLYSI HRITMFRKNL CYSRGYVNTI QHCSY
//
DBGET integrated database retrieval system