ID A0A077Z576_TRITR Unreviewed; 941 AA.
AC A0A077Z576;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=RNA 3' terminal phosphate cyclase protein {ECO:0000313|EMBL:CDW54813.1};
GN ORFNames=TTRE_0000308301 {ECO:0000313|EMBL:CDW54813.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW54813.1};
RN [1] {ECO:0000313|EMBL:CDW54813.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW54813.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235}.
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DR EMBL; HG805917; CDW54813.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077Z576; -.
DR STRING; 36087.A0A077Z576; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR GO; GO:0032299; C:ribonuclease H2 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR CDD; cd09271; RNase_H2-C; 1.
DR Gene3D; 2.40.128.680; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.65.10.20; RNA 3'-terminal phosphate cyclase domain; 1.
DR Gene3D; 3.30.360.20; RNA 3'-terminal phosphate cyclase, insert domain; 1.
DR InterPro; IPR007242; Atg12.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR013924; RNase_H2_suC.
DR InterPro; IPR036553; RPTC_insert.
DR InterPro; IPR024512; Ser_palmitoyltrfase_ssu-like.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR NCBIfam; TIGR03400; 18S_RNA_Rcl1p; 1.
DR PANTHER; PTHR10760:SF2; LD13476P-RELATED; 1.
DR PANTHER; PTHR10760; TORSIN; 1.
DR Pfam; PF04110; APG12; 1.
DR Pfam; PF08615; RNase_H2_suC; 1.
DR Pfam; PF01137; RTC; 1.
DR Pfam; PF05189; RTC_insert; 1.
DR Pfam; PF11779; SPT_ssu-like; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR SUPFAM; SSF55205; EPT/RTPC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS01287; RTC; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 134..466
FT /note="RNA 3'-terminal phosphate cyclase"
FT /evidence="ECO:0000259|Pfam:PF01137"
FT DOMAIN 309..412
FT /note="RNA 3'-terminal phosphate cyclase insert"
FT /evidence="ECO:0000259|Pfam:PF05189"
FT DOMAIN 867..926
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
SQ SEQUENCE 941 AA; 105578 MW; 995D61F4E7EA2146 CRC64;
MSVVALLTRW PKRAVESIQW LYLEYTMVTS LYMMEPWERY AYNTIFSVAF IFASVSRAMA
EEGTSSPSVP GKIELILKPV GDAPIMKDRK WEVATTRTVA WLHLFIRKYL RLNDAESLFL
HPLAMGDRTS RLDFKGNNFM RIRLVLSLLS RRPIRISEIR SSSTEPGVKD FEVNTLKLIC
SLTNGSVVDL GPTGTELFFK PGFLTGGSFD FDCGKERGIG YYLELLCYLA PFCKMPLNVV
LHGVTNCSGD PSVDLIKFGW LPLMRRFYAD AEGLDLKIVN RGFMPNGGGK VVFSSPVCRY
LRPIQLETSG QVRKVRGIAY SCRVSPTMAN RCMATCKASV KQYLSDVYFY SDHRKGEAAG
QSPGFGVLLS AETTEGVFYI SEAMSNPVDS ELGPAVPEQV GSETALSLFS EIYRGGCCDT
TAQCLAVLFM ALCQKDVSKL VIGPLSEYCA YFLRHLKDFL GVVFKIDELK PSLKSSDGGG
GPNKESGSNC LPGKVKLTCV GKMDKAQVHS IPAKISYDGP AQVETYFDST RVHHEDGTET
ATFRGRPLNG MTSRLPEGYR LYVTENTSKG DNVQLTALKE AEQFTVWSLD SDPNSAKMLK
ALAWLDVASE VFVGFAVVEA PVRPGYFASL YNSVTSLSCY FYECCQDEYI KIDLPGLRRE
LKQRVYGQHL VINTVVNALA AHFKVADKKK PLVLSFHGWT GGGKNYVTSF VARHLYKKGL
QSRYVHQFSG SLHFPEPQKS RQYTVQLQTW IRGNASICGR SLFIFDEVEL MPAGVLDGIK
TFMEYREDVD RVDFRDCVFV FLSNTAGSEI AKSTYEAWKQ GRRREDISLH EIEKAIVESV
FNEKGGLQYS HLISRSLIDH FVPFLPLERD HVKLCIRDEL LNRGWTGSID KTMLNEIADQ
LSYFPKDVGL YSSTGCKHIW QKVGLYMEER ADSNFLQHAE F
//
