ID   A0A077Z6W7_TRITR        Unreviewed;      1121 AA.
AC   A0A077Z6W7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   22-FEB-2023, entry version 39.
DE   SubName: Full=GTPase activating protein pac 1 {ECO:0000313|EMBL:CDW56162.1};
GN   ORFNames=TTRE_0000443701 {ECO:0000313|EMBL:CDW56162.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW56162.1};
RN   [1] {ECO:0000313|EMBL:CDW56162.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Aslett M.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW56162.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate host-
RT   pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HG806013; CDW56162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077Z6W7; -.
DR   STRING; 36087.A0A077Z6W7; -.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23175:SF23; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
FT   DOMAIN          90..211
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          442..654
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          44..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          949..1121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..390
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1004..1018
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1034..1073
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1121 AA;  124478 MW;  02817AA46102D047 CRC64;
     MLAGPRFVRR RNGRREKRIT RFINLYNSSQ VSSMRANIGE GRLGEAQDDS CSLSPSCSSS
     LSDSSIPKAA GPQPSAPLSV GATAPTQSDT IYREGILYHK QPSNSGRSSH DRSWQLYWAF
     LIDHTLHLCP EKSMLAVSPT SVAAQKFVHF IREKASLSID VRSCIADIAY NQVKRKSVFR
     CITVKQSEHL FQAVDDKDMI GWIEALQSCA KGAEQVLPPL ARNGHLFDVD GGLGGAHAST
     RRRCLVGIMA NWALRPLAHL CIRGCDRSGA SFNEMPFNQR QLVDAIVSTR PFYCNYMKKT
     TVLLVYGCYV SPAPCESLFK ETVSPSSLAL IIKRYERQSH SSSSSVSPSV KLKKSVQSPS
     VKGGALKAMA EEGAPEQAPP PPPPAPPAAS SSQQPHHSEA TLKRVRKWCK TRFPAAANTA
     TVATSQTLRD DQNRPCSAVF GLHLEDCLTT GETDYVPLII QLCVKVVEAY GLDTVGVYRI
     PGNTAAVNTL SASLDQGFEF VEFDDIRWRD VNVVSSLLKA FFRKLPDPLL TSNLYRHFIE
     ANRIESPELR LKTLRDLVRK LPRHNYETLR YLMHHLNRVV AHSAINKVLP ARLITCMLGM
     ILVRLFKMEA KNLALMFGPS LVRPSGENMV AMVTHMSDQC KIVESLIVYS SWNFSAVGYL
     ARIRPSNRST LQALRLDNCW TLSAIPNEVL LTNRSLVQSI RIVTFAGFVD LKKAKENIVK
     NLVNVRAVKN ECTPVPQTAL SGSPCDERNI DEEIARAYRL DSLNEASSGG GGGTIYDEQM
     SRSVLPESTR ELIEAAEDYK RSREEQIYTA RRIFIAGGTP TESVDNKINL LAQHCRHLNI
     NNADSLDVLS PETREKIKQF QRGHPLWTSG RAPLNFPQGP SAMTTSQQVD ADLLELRGRG
     NSLSRSRPLG MSSSCDSLDE AHFAGGGGHP SPTSKSYDFA GTQLSEAVAT KEAGNDVEDN
     GKQQHQQSLL NRGRLRHVKP EFSFFRRTVA NDCPPTGQSE GGESRHEGAS KEGRQHQHRQ
     YNIGNLLKFS RKAAALPQER RRDLRRHTLG SMETEQFRSG RRQLRHKVFN DDEEGDHDDD
     GGRGDEPVQL WLKESPLRRS NPDMSSPSVP SMGDRPLWVH S
//