ID A0A077Z8D0_TRITR Unreviewed; 1008 AA.
AC A0A077Z8D0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=tryptophan--tRNA ligase {ECO:0000256|ARBA:ARBA00013161};
DE EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
DE AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030268};
GN ORFNames=TTRE_0000416201 {ECO:0000313|EMBL:CDW55888.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW55888.1};
RN [1] {ECO:0000313|EMBL:CDW55888.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW55888.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
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DR EMBL; HG805990; CDW55888.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077Z8D0; -.
DR STRING; 36087.A0A077Z8D0; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd03236; ABC_RNaseL_inhibitor_domain1; 1.
DR CDD; cd00806; TrpRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013283; RLI1.
DR InterPro; IPR034348; RLI_dom_1.
DR InterPro; IPR007209; RNaseL-inhib-like_metal-bd_dom.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR002306; Trp-tRNA-ligase.
DR NCBIfam; TIGR00233; trpS; 1.
DR PANTHER; PTHR19248:SF16; ATP-BINDING CASSETTE SUB-FAMILY E MEMBER 1; 1.
DR PANTHER; PTHR19248; ATP-BINDING TRANSPORT PROTEIN-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF04068; RLI; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01868; ABCEFAMILY.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..85
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 80..325
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 350..573
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1008 AA; 112661 MW; AF90C219B5D2EF01 CRC64;
MPKPLRSSNS EQSKMTRIAI VSADRCKPKN CGQVCRKSCP VVRMGKQCIE VTATSKIAFI
SETLCIGCGI CVKKCPYGAI SIINLPSNLD KDTTHRYGFN SFKLHRLPTP RPGEILGLVG
TNGIGKSTAL KILSGKLKPN LGNFKNPPEW HEILAYFRGS ELQNYFTKLL EDNLRAVIKP
QYVDQIPQAA KGVVRDMFLK KDDLGRMEEM ADMLDLNKLM DRNISDLSGG ELQRFAIAIV
CIQRADIYMF DEPSSYLDVK QRLKAAVTIR SMVNSTNFSI VVEHDLSVLD YLSDFICVLY
GVPGAYGVVT MPFSVREGIN IFLDGFVPTE NLRFRESSLS FKVSDQSLDE QIKRVSRYHY
PSMKKKLGNF ELTVEDGEFT DSEIIVLLGE NGTGKTTMIK LLAGKLQPDE ESGEIPQLSI
SYKPQKISPK SQCKVSELLR AKIPDAFIHP QFSADVLKPL DLDNLKDQEV QNLSGGELQR
VALALCLGKP ADVYLIDEPS AYLDSEQRLH AAKVIKRFIL HAKKTAFVVE HDFIMATYLA
DRVVVFSGNP SSEAVAASPQ SLLNGMNKFL GLLDITFRRD PNNFRPRINK LNSVKVTRLL
YFFAANCFYY YCFIFSAGYG AEKVRKLFLS RRLIIVWIGT LTSCYKAILA PLRMAARSVV
TSISRGLCTS GHTSIGEVVM SGIQPSGRMH IGNYFGAASQ WLRLQSDPSC RRLYLCIADL
HALSSSCDPE QLRRDVITMT ASLMACGLGP PKCVIFQQSS VSCHGNMYWL LGTFVTLPQL
QHLTHYREKA TKYKDGNVPL GLFTYPVLQA ADILLYRPDV VPVGEDQTQH LRLTQKLARS
LNVRYKSALF PIPRQMMAQW PRIKSLRNPA KKMSKSDDDV KGCVYVDDPP EVILERVKKA
ITDFVSAVTY EPEERPGVAN LIRIYCAATG QSESQVVDYF VGKTTAEFKL ELADVLAHTF
RPVREQVKRL LSNQDVILKT LANGAKEAEV VAMETLESLK RAVGLQVK
//
