ID A0A077Z8F4_TRITR Unreviewed; 2549 AA.
AC A0A077Z8F4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Spectrin and RhoGEF and CRAL TRIO 2 domain contai ning protein {ECO:0000313|EMBL:CDW56496.1};
GN ORFNames=TTRE_0000477601 {ECO:0000313|EMBL:CDW56496.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW56496.1};
RN [1] {ECO:0000313|EMBL:CDW56496.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW56496.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; HG806046; CDW56496.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077Z8F4; -.
DR STRING; 36087.A0A077Z8F4; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 2.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 2.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 1328..1550
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1567..1673
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 2071..2246
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 2264..2372
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1695..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1869..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2438..2549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1876..1892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2449..2474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2475..2492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2493..2511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2519..2538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2549 AA; 288878 MW; 575D0D9536D35ABC CRC64;
MAIADLSTQT NSLGNLLKAS DVKHILNERL ALLTGARDRF GRPVITFPLR EHPEKVNVEE
LRMLLLYLFA LPSDESKGLG FVVLIDMRNK VSWNNVKPIF RCLQDIFPGQ VLAVYLVKQD
SFWEKHKATV ASNKYKFEVH CVSPENLHKY IDPNQLTADF DGTYPYDHEE WLSLRMALES
FIWRAMDVLR VFENIQNELQ HGDLPADIAQ AKEALEEHAK LKKRIGKAPI DNLEEEGQQL
IQRLSGSEEP QKCASASECG GGGGSGRDYP CNPDFVCAVP HISFLLNNLR ATRQNLYSQW
QTHKVRLDQC FQLKLFEQDA DKVSCFCCFF LNPIVSIYRF HAFLFFLHQI TFQMFVWIRQ
HVDIFLVSYS DIGESQEGAT AAQQEHEQFT RAAMNTYVNI NHIMTVAQRL LENGHYASPI
IRAVANRLER DWKTFINALD MRTSVLRLSL QFYCKTNQYM TNIKNWLAQC SVESELPATV
GALEASISEH EQLYESVSQL YTEATNDGNA LSHSLQSPPA LVNSSGSKIA GAAEGDAAGC
SSSSTCSSPK ASGPTDYCHG AAHVLETMHK IHGYQRQLED AWQQRRIKLH QKLALLLFQQ
DVKQVLDWLD QHGETFLRKN QGIGKTLQRA RGLQRSQQHF ENVAKNTYTN AEKLLVAAED
LAATTGEWHP EEVYHTAQHL RSRISVFAKR VQARRNLLNF SVLFHTHFNE IMAWMNDLER
TESTINVIGN TIQECEQNFD QWLARAEATR QATATTRNEG VQLVSLLRQQ SVLEGSDNVE
SIAFVEEMIN QVDAKQASFE EKWKVQRFQL NIALQFRVFE QDSISVISQL DGWSEDMKVM
SNNVSMDQVE KIMPLHQENT TQVQDAIADI MQSAQDVIQL IENSGVYLLV SSGSSVLDCI
IRLTDRISQQ QHDVLALADS VQAKLEQIVS LGQLQNLANQ VVAWINNEEQ MLSATFAVPS
VLSEATQLQS DYRFCCYSML CLLQKTNEST LALKQKAEAM LSKDHCEVNV VRKMVDDVIG
RWRRLIALTD ERHKLLTSAV TYYKTLDQML PVLDNLEEDY QTERDWCAWY TKQAGQEAKT
SSKAQDKPSY VQQLISKHID NKERFLRGCT YARKNSDIFL KYVRRSLYQP QQQSAVISCK
QVEARVLQSL EHLRIRENQI LSLWTKKKRR LDQCQEYVLL EASACKLLDW IHEEGESYLA
AHMGNVLSTS IADELLKEHE AFVATAKEQR DSVRIFLDLG EKMLGKDGQH LHANDITQWV
KTVKQRYTEF SGKMDAYRMK LESILGRSGK TSRDLALDRQ SDSSLDQKLA DQNRKESIEG
VKRKSSKRKD FIMAELLQTE RVYVSDLEAC IKYYLQSMET AQNVPASIRG KQDVIFLNIK
QIYDFHKECT HMYAVRDVET AANASFSIKA ATVVLFRIFL QELEKYESLP EDVGHCFVTW
AEKFQMYVSY CRYKPDSNNL VTQPAASQFF DVRLFLIVRR NQLLVLTVQE VQKNVQLSLP
LAAYLIKPVQ RITKYQLLLK DLLNCCEEEK GEIKDGLEVM LNVPKKANDI LHLSMLEGCS
DVDALGDVLL QEMFIVWDPR QLIKKGRERQ VFLFDICLVF SKKFVDQAGR TKYMYKSRVL
TSEINVTEHI EGDECKFALW TGHVPVNETR TVLKAPTLES KLTWVRRLRE LISDRILQFE
LPYLPPARLR QQANFSAESE QNRISNQSDT GSANTEASSE FALPCVNTTN AQLSGGNDSA
KTDEEPNGSV DQVYIVVSDH MPSPDSTTNG EIVVRAGERV ELLHGAESLP NLTYVRVIDE
EAPLRKGYVP TSKLRSASNC FNTFGDTDDY NDDRERTLRQ IDEAEEADKM KRKTLKKWFS
LSSRQKLVRH QYHSDRAPSS AGSSRNSSTT SFNGAAEEAS VISVAAFPGS LAPLNCRPSS
LLSRAPAVVR TDSINVAADT AASVGVGSAE EDLSFLPQDI EIPPPMESLA SEKLMATGSD
KNNSVSVCSV CDQMKITKFS TTDKFLATTS RRCMSAVEIG EEEVAGEIDK RILRLQLRSP
ELNMPASTEQ SYKAASESVV PVNEQQAARE KRRYVLQELV ETERDYVKDL GSIVEGYIAT
IDSMELPEDK KGRERIVFAN IQQIFEFHKN IFSKEIEKCL DDYEAAGRAF VKYERRLHMY
VVYCQNKPKS EYLVSEHENF FNEIRQKLGH RLTLTDLLIK PVQRIMKYQL LLKDILKYTE
RAGEDTTILQ KALQVMHVVP KACDNMMHVG RLQGFDGKIT SQGKLLHQGT LLVADGPSGQ
QLKLKERRVF LFEQSVIIAD CILPKREFAS PNYIYKTHIM VNKLGLEVDV PGEPLRFIIK
NKDPSNQADT VVQASTLEEK EQWIGFIKQL LDTQMDFLKA LQHPIAYQKG LSKEYSYTLK
FRSTATFTLV FVSSDSKEEE AGRANAEAFV RHMPSVIDET PLPVSGRRSL QHVDTSRNCN
VASDSSSSSQ HRRTGHADGS SDQEKKIPGR PTDLTTKEST IGSSADTASP RSKTKLFGGI
RQTLKSKSAG SSSKGVKSPA SPLPGLKPK
//
