ID   A0A077ZAS8_TRITR        Unreviewed;       609 AA.
AC   A0A077ZAS8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Forkhead box protein O {ECO:0000256|ARBA:ARBA00039893};
GN   ORFNames=TTRE_0000521201 {ECO:0000313|EMBL:CDW56929.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW56929.1};
RN   [1] {ECO:0000313|EMBL:CDW56929.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Aslett M.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW56929.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate host-
RT   pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC       ProRule:PRU00089}.
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DR   EMBL; HG806097; CDW56929.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077ZAS8; -.
DR   STRING; 36087.A0A077ZAS8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd20032; FH_FOXO; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032067; FOXO-TAD.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR   PANTHER; PTHR45767:SF2; FORKHEAD BOX PROTEIN O; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF16676; FOXO-TAD; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          126..219
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        126..219
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          203..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..568
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  66597 MW;  E50AF517467E868B CRC64;
     MSSSSQAGRS EMLRPGMTIE PFAKNKVTCN VSVPVHDSDD FDPQPRDRCN SWPLQKSSRG
     DFLHHTSPLI HEEIPEEVSD SGSTNDLAVN HGPVHSSAEV LASAMGATGI GDFATNKRTS
     SRRNAWGNLS YADLITQAIL SAPEKRLTLS QIYDWMVKNV PYFRDKGDSN SSAGWKNSIR
     HNLSLHSRFM RIQNEGPGKS SWWVIDPDAK PGKSSRRRAG SMEISKKLEK KRGRVRKKME
     QLRSVSGGTL ADGGISVLSP SISESSDLLD GGAGGGGSSM MPFTLSPAND FRHRSNSAVS
     SYSVGGACLS PKYESHFEDW VDDVQSMHGP SGGEPYSAEL VESMSHSMNL VEPPPPYPSN
     AAQPFLFSAE DDGVPTHVQH ASPAKYLVVN TQQQQQQQQP QQQQQQQQQQ QAQRHMGANS
     FSTSAQGLSP SSLVSGKNPV LYQSASAKAS EQHLPQYRDL YGGSQQATSS NRMLRQVLTK
     PGTSNSVGFL NQNSVRSVLM QDLSQMLRIG PQQAQPSQQM RQQQNRLTTV SSSLLPVAQE
     LPFAPPPPPL SHPSAQQQQQ QLHPNGQLPS ELSDMMYDTD IQCDIDQVIR HELNIAGNLD
     FSADNFGNI
//