ID A0A077ZE30_TRITR Unreviewed; 739 AA.
AC A0A077ZE30;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=TTRE_0000694001 {ECO:0000313|EMBL:CDW58616.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW58616.1};
RN [1] {ECO:0000313|EMBL:CDW58616.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW58616.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR EMBL; HG806380; CDW58616.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077ZE30; -.
DR STRING; 36087.A0A077ZE30; -.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039184; SARM1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR PANTHER; PTHR22998; SARM1; 1.
DR Pfam; PF07647; SAM_2; 2.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 396..460
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 542..686
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 739 AA; 83358 MW; FF69F32C8BF83330 CRC64;
MPKGHREIVP YGILEDNGSP IFGRKHSFEY GAAKHLHTEL LVSKHTLKGK MNKFQRLIDR
AVSLLSIGNV NSICEGCALL ARVLKSSWTT PKIGSDLAHG LCDYIRDSGF LDTLLQLFLH
PRSTDQVKVA SGLVLVECLS SSNREYLVQN NHLEEVVNVC KAMKEGDKLR TSVSLFESLF
KYSVESNARL IELGALDHIL AACKATTCRK TFRYASLALA NLSMYSDSEC QQKMIAKNVP
DWLFLLASSQ DDVTRYYACL AICALVSNKE VESAVTKSGT LALVEPFLLS HKPEDFSQFD
YRHQQGRSKE WLELLMPMLS AKRREPRSMA AFHFAIEASV KKEQEALSLL LEIGAVDALK
QVASMPDEVA PKFASQALHI IGEEVPYKLS QQVPFWSVED VQYWVSQIGF EKYSPLFSEQ
KVDGDLLLLL TDAELERDIG MRSGLLRKRF MRELESLKMA ADYTSVDETH LDRFLVSVSP
QFSVYTYQLL ELGVDRSTLS SMSNEILKSE CGISNPVHRL KLLQSIEDCK HVEDLDIAIL
SKHIDIFISY RRSTGNQLAS LIKVLLQLRG HKVFIDVDRL YAGNFDSSLL KNIQAAKHFV
LVLTPRSLDR CLGDEECQDW VHREVKCALE HNKNLIPVFD PMFEWPDENQ IPADIRAITR
VNGVRWVHEY QEACVDKLEK FINGELNVNR GFFPLPQFGS LSRSMFVNSS PTTMNVSGSS
STDMVIESLA KSRPRGNSQ
//
