ID   A0A077ZFJ6_TRITR        Unreviewed;       689 AA.
AC   A0A077ZFJ6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Type III restriction enzyme, res subunit family p rotein {ECO:0000313|EMBL:CDW58313.1};
GN   ORFNames=TTRE_0000662001 {ECO:0000313|EMBL:CDW58313.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW58313.1};
RN   [1] {ECO:0000313|EMBL:CDW58313.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Aslett M.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW58313.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate host-
RT   pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   EMBL; HG806309; CDW58313.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077ZFJ6; -.
DR   STRING; 36087.A0A077ZFJ6; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016891; F:RNA endonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR   CDD; cd18034; DEXHc_dicer; 1.
DR   CDD; cd15903; Dicer_PBD; 1.
DR   Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR14074:SF16; ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I; 1.
DR   PANTHER; PTHR14074; HELICASE WITH DEATH DOMAIN-RELATED; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT   DOMAIN          42..221
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          377..559
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          594..687
FT                   /note="Dicer dsRNA-binding fold"
FT                   /evidence="ECO:0000259|PROSITE:PS51327"
SQ   SEQUENCE   689 AA;  77260 MW;  B0A5556DFB70DE9B CRC64;
     MGRLGDKSRY LRAISSPASS LNGSEVAADE KCYAPRDYQI SLAEKAVEQN LLIPLRTGSG
     KTLIAVLLIK MLSRQIRIPL QKGGKRSIFV VNTVVLVKQQ AAYIRKHSDL KVAELCGCTG
     GDFYSKAEWD ALMNNFEVVI VVVAQLFSDG LNHAFVAMEQ FNVVVFDECH HATGNHPYCL
     AMNHYVRCPP DRRPRILGLT ASVLNKGNSS VNALTEFAKL EQTLCSRIEA STWFLAACAY
     SAEAKVRVLC CEDKTSRSYA QLENELTTKC QEIIDFIADV KYSFSYDKKA LGSISKIFNR
     MQNVVDHLGL WPALKACNEQ LEELAAIGRT ATSDETMSFV ALGLTQIRCL KFLLEAYVKN
     VKSCDELKRY VSPRLWALIE LLREYNGRYF AATKSNDDND PFCGIVFVER RYTAYLIHAL
     LVAIQSWEPK TLNHLKVCFV VGCNNVNSFV AVNRHEYRQQ EENILRFQSG GKNFIIATSV
     LEEGFDVQRC NVVVRFDPPI SFRSYIQSKG GRARKHGSEY VIVCKTDEEE KVKKLLLGFL
     ETESKLANYE SSADFGDMYC DRDTEMDRLV APYNATLTSD DGSKRVARIT LSTATRIVHM
     FCDKLPEAVV GKAKIMYKFR THFDALGTAT FTCIIEIPSI QLSLTGLAMP TRDLAKRAAA
     LETCKVLHVS GRLNEHLLPF GVRDLKPVS
//