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Database: UniProt
Entry: A0A077ZJU2_TRITR
LinkDB: A0A077ZJU2_TRITR
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ID   A0A077ZJU2_TRITR        Unreviewed;      1470 AA.
AC   A0A077ZJU2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   03-JUL-2019, entry version 20.
DE   SubName: Full=DUF972 and Thymidylate kin and PSP1 and RecR and DNA pol3 delta2 and Toprim 4 and TP methylase and YbaB DNA bd domain containing protein {ECO:0000313|EMBL:CDW58870.1};
GN   ORFNames=TTRE_0000719601 {ECO:0000313|EMBL:CDW58870.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW58870.1, ECO:0000313|Proteomes:UP000030665};
RN   [1] {ECO:0000313|Proteomes:UP000030665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Aslett M.;
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW58870.1, ECO:0000313|Proteomes:UP000030665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate
RT   host-pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HG806438; CDW58870.1; -; Genomic_DNA.
DR   Proteomes; UP000030665; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   CDD; cd11648; RsmI; 1.
DR   CDD; cd01025; TOPRIM_recR; 1.
DR   Gene3D; 3.30.1310.10; -; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   HAMAP; MF_01877; 16SrRNA_methyltr_I; 1.
DR   HAMAP; MF_00274; DNA_YbaB_EbfC; 1.
DR   HAMAP; MF_00017; RecR; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR004622; DNA_pol_HolB.
DR   InterPro; IPR000093; DNA_Rcmb_RecR.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR007557; PSP1_C.
DR   InterPro; IPR023627; Rcmb_RecR.
DR   InterPro; IPR023628; Rcmb_RecR_C4-type_Zn.
DR   InterPro; IPR015967; Rcmb_RecR_CS.
DR   InterPro; IPR008189; rRNA_ssu_MeTfrase_I.
DR   InterPro; IPR018063; SAM_MeTrfase_RsmI_CS.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034137; TOPRIM_RecR.
DR   InterPro; IPR010377; YabA.
DR   InterPro; IPR036894; YbaB-like_sf.
DR   InterPro; IPR004401; YbaB/EbfC.
DR   PANTHER; PTHR46111; PTHR46111; 1.
DR   Pfam; PF04468; PSP1; 1.
DR   Pfam; PF02132; RecR; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   Pfam; PF13662; Toprim_4; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   Pfam; PF06156; YabA; 1.
DR   Pfam; PF02575; YbaB_DNA_bd; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF111304; SSF111304; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   SUPFAM; SSF82607; SSF82607; 1.
DR   TIGRFAMs; TIGR00103; DNA_YbaB_EbfC; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   TIGRFAMs; TIGR00678; holB; 1.
DR   TIGRFAMs; TIGR00615; recR; 1.
DR   TIGRFAMs; TIGR00096; TIGR00096; 1.
DR   PROSITE; PS51411; PSP1_C; 1.
DR   PROSITE; PS01300; RECR; 1.
DR   PROSITE; PS01296; RSMI; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030665};
KW   Methyltransferase {ECO:0000313|EMBL:CDW58870.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030665};
KW   Transferase {ECO:0000313|EMBL:CDW58870.1}.
FT   DOMAIN      211    306       Toprim. {ECO:0000259|PROSITE:PS50880}.
FT   DOMAIN      924   1009       PSP1 C-terminal. {ECO:0000259|PROSITE:
FT                                PS51411}.
FT   COILED        8     35       {ECO:0000256|SAM:Coils}.
FT   COILED      935    962       {ECO:0000256|SAM:Coils}.
FT   COILED     1140   1174       {ECO:0000256|SAM:Coils}.
FT   COILED     1328   1348       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1470 AA;  167282 MW;  55E07AA1C9E4C85B CRC64;
     MMRGMGNMQG MMKQMQKMQK EMVKAQDELN VKEFTGSSTN DLVTVTFTGD KNMKAMTINP
     ELIDPEDPDM LQDMIVLAVN DAITKITKET DQTMGKYTKG LPGIADVEQV PTWSSKAERV
     REAFLEERKD RMQYPEPIAK LIESYMKLPG IGQKTATRLA FFTIDMKDES VNEFARSLIS
     VKRDLRFCSV CGNITEEDPC EICSDTTRDR GTILVVEEPK DVMSMEKVRE YHGLYHVLHG
     VLSPMEGTGP EDINIAPLIK RLHDDEVKEV IIATNATTEG EATAMYLSRL IKPAGIKVTR
     LAYGLSVGSD IEYADEITLL KAREKIKIIL GDKNVNGLFI TIEGPDGAGK TSVLNELYPR
     LQLTAKRSIV KTREPGGIPI AEKIRHVILD PSNDRMDDRT EALLYAAARR QHLIEKVWPA
     LDEDKIVLCD RFVDSSLAYQ GAGRGIGIEE VAKINEFAIE GTTPDITLYL DVDSDTGLQR
     IMKNRTNQID RLDSEGLQFH QRVRHAYLKL AEENPDRIIK IDARKRLDEV TFRWMDKSLI
     LLKLKSAVRQ YLSCQSKAST SIKMEEAKKL QTIQPIVFRQ LQNSFEHGRL AHAYLFEGDQ
     GTGKAELALW FAKHQFCLNL QEEMPCETCN NCLRITSKDH PDVVEIEPDG QSIKVDQIRA
     LQSELTKSGF ESAKKVVIIH QAEKMNMNSA NSLLKFLEEP PANFMIILET QSLGKILPTI
     RSRCQIIHFQ ALSTERLQSR LEAEQIPEKT AKLLANLTNS YTKAVEISKD EWFNEARDVV
     IQWFNYLEKN DPQAFIYVQK KMVRTFKDKA QQQLAFEMLA YFVKEKRDQV MRQNQIGVEK
     YNYLLEDVLS ASQKLEANRV GRTMVEVVGV RFRDAGHIYY YAPGKNEYFY NDKVLVESQQ
     AHQIATVAIP KIEIEKKDLS DDLKTILHKA SDKELKKVAQ NEADAEAAFK TAKEKIRAHE
     LEMKLIRVEY TFDRSKMIFY FTADGRIDFR ELVKDLAGVF RTRIELRQIG VRDEAKILGG
     IGPCGRPLCC STFLGDFIPV SIKMAKDQGL SLNPTKISGL CGRLMCCLKY ENGEYEAAKK
     EMPDYGKEIN TPEGRGKVIG LNLLSKVVKV RLFGRDATID FDYQELVEAE LDMQKNLEDL
     VSMKETLLEL VEKNAKLEME NERLRERIRE IDEKKSPVLD ERQELSESRL NLEKIYEDGF
     HVLPTPIGNL EDMTFRAVKT LQTVDLIASE DTRNTQKLLN HFDVKVPQKS LHEHNYNERI
     PELLDFLKKG RSIAQVSDAG MPSISDPGHE LVVACIEEDI PVVALPGATA GMTALIASGL
     LPQPFYFYGF LQRKKSAQKK ELEELKNQTA TLIFYESPHR VKETLKNISE ILGNRDVVIS
     RELTKLYEEY LRGTVTELMD YLSEHSLKGE CCLLVSGTTE VLEEEVFQGT LKEQVEALVE
     EGQLTKEAIK SVAKRHGLKK QDVYREYHEL
//
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