ID   A0A077ZQT6_STYLE        Unreviewed;      1245 AA.
AC   A0A077ZQT6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Mitochondrial helicase twinkle {ECO:0000313|EMBL:CDW71750.1};
GN   Name=Contig10948.g11702 {ECO:0000313|EMBL:CDW71750.1};
GN   ORFNames=STYLEM_699 {ECO:0000313|EMBL:CDW71750.1};
OS   Stylonychia lemnae (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX   NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW71750.1, ECO:0000313|Proteomes:UP000039865};
RN   [1] {ECO:0000313|EMBL:CDW71750.1, ECO:0000313|Proteomes:UP000039865}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=130c {ECO:0000313|EMBL:CDW71750.1,
RC   ECO:0000313|Proteomes:UP000039865};
RA   Swart Estienne;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CCKQ01000660; CDW71750.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077ZQT6; -.
DR   EnsemblProtists; CDW71750; CDW71750; STYLEM_699.
DR   InParanoid; A0A077ZQT6; -.
DR   OrthoDB; 9502at2759; -.
DR   Proteomes; UP000039865; Unassembled WGS sequence.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd01029; TOPRIM_primases; 1.
DR   CDD; cd01122; Twinkle_C; 1.
DR   Gene3D; 3.40.1360.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR   InterPro; IPR027032; Twinkle-like.
DR   PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR   PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR   Pfam; PF03796; DnaB_C; 1.
DR   Pfam; PF13155; Toprim_2; 1.
DR   SUPFAM; SSF56731; DNA primase core; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:CDW71750.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000313|EMBL:CDW71750.1};
KW   Hydrolase {ECO:0000313|EMBL:CDW71750.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:CDW71750.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000039865}.
FT   DOMAIN          499..748
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   REGION          27..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..863
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          990..1066
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1198..1229
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        312..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1019..1066
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1245 AA;  144564 MW;  417FEA8E3C0FF81A CRC64;
     MIIKKKAANL INQCIHKQVR LAQQPCNKFS SRSNNDGGWP SSSGAPQMQV QLANKGNQFD
     RNQQSSSSPF NVRINGAPNN INKEREDANN NVEFNNQPEQ NKSFTSKYYD IKTQEIHEFL
     QLYKIRYQLQ GSEIVIYTCP LCMKPHNNDP KNMNTCRINA IKGFFNCFRC GSSGSWYGFK
     NKILHNHFGT SPEDLVFKAD QSPGTKQFTE GFQFKQDWLP DYSQRNQDRY EIEDAHKVFI
     QLKRNIYPEI NEYLTGTKDP SEQRYLKKET LEIYRIGVGK EKFRNSNDQL SFLDSVYFPL
     YAPKSKKTKQ KKDKQKVEDF GKNQSTLEYE KNQKENAERE INTEEYEMVK MKIRAIGSEN
     KANMRFLPVG IITEGEYDAM AVYQETGLPA ISLPNGANHL PVQFIPFLER FERIYLWMDA
     DEVGRIAAEK FSNKLGQMRT IIIDTKMYDE NGPKDANDAL RRGIDFKKIF QENSRRLGDQ
     NLLTVFDLRD KIVKRIMNYQ ELTGIQSKYF TFYNRTLKGF RRGEMSILTG ATGSGKTTFL
     SQLSIDFVSQ GVPTLWGSFE IKNEILASTM LQQYTRQKLT NESMEKIDQH IEQFGLHPLY
     FLNFYGSTHI DLLIETLNYA IYNYDIQFIC LDNLQFMLSQ QAQGTFKFDL QDKVASYLRQ
     LATDKNIHIA VVVHPKKVED DNNLTVGSIF GTAKITQEAD SVLILQKHNV PGLRTIQVKK
     NRFDGEVGEV SMLYNQENKR YFELTPEEKT SLLLKNGSSQ NIIKQRKLKY GDVEPALLKD
     KVDVKIEKPS KSKTIKNKVS EIAKKDLNFH GKLREHINKK EPEENLINQK NSHIYHTSDN
     SSNSSGSDNE GGEGSKGRSV SSDFTGSMME ITAASEFPEI QVDELKSIVI DDNDLLAPPE
     DLSVTEIEVE MSMRQERALT QEESSNLRKQ YSQEMLNDQS QPITPQQQQA WEVHFKRINE
     QSLEFKSTER FYYKRYDSLA QVLKTNSFNI DPSNIVGNYD ENNEESQNIE EENKQGKSDQ
     GKNLSQQILQ NDKQATNTRN FSKKTTYKSS ESNMFESKQM QLNKKQSNPS VDYINYRYTQ
     TGIIQDEALR EISIKQEEYL ELDKILRPKF LKEVKFIESF FKDGRVKSRE EVESSSSKRT
     NYSRAYYEEY QLIQQKNNDD YDPIAIIQDS DNEVEIKSRQ GLINEKFDIK HLERSIENEI
     QEQIEDDLNR EIEQDQENLN QRMLRSMNEE EKTKRIKELL SKAAK
//