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Database: UniProt
Entry: A0A077ZYS1_STYLE
LinkDB: A0A077ZYS1_STYLE
Original site: A0A077ZYS1_STYLE 
ID   A0A077ZYS1_STYLE        Unreviewed;      1554 AA.
AC   A0A077ZYS1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   03-JUL-2019, entry version 26.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=Contig16336.g17402 {ECO:0000313|EMBL:CDW73683.1};
GN   ORFNames=STYLEM_2668 {ECO:0000313|EMBL:CDW73683.1};
OS   Stylonychia lemnae (Ciliate).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae;
OC   Stylonychia.
OX   NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW73683.1};
RN   [1] {ECO:0000313|EMBL:CDW73683.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=130c {ECO:0000313|EMBL:CDW73683.1};
RA   Swart Estienne;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; CCKQ01002574; CDW73683.1; -; Genomic_DNA.
DR   EnsemblProtists; CDW73683; CDW73683; STYLEM_2668.
DR   OrthoDB; 20210at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      901   1367       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1446   1532       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      384    416       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A077ZYS1}.
FT   COILED      180    200       {ECO:0000256|SAM:Coils}.
FT   COILED      249    269       {ECO:0000256|SAM:Coils}.
FT   COILED     1462   1482       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    384    406       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A077ZYS1}.
SQ   SEQUENCE   1554 AA;  181522 MW;  D23958760510508A CRC64;
     MRRMDLINSV RDSIDSSLRK GLINRQQSFD QQSFSIQDLD SQIDNMSDSY LDQINKTPDF
     KLDQLQSDHK QSAKVNAIEP ETFDQQFLKY SLDIKEVKSL VNLWKEEFVR RKHQKLPELE
     RAQMKDDSRL GGYSESINKD QKVIQYLLKH LRTKTQNSEK FETVDNSMYK EIDIVDYEAL
     QMFIQSKEEL QENEGDLQER YQMLGFFNMR QMQEARHQKA VQKNFQQQVQ GLDEEEKIQQ
     DEVEVLDIME SLKDQYDNIM NRVKDHRQAK AKYKTGKIGS DIQNNKSIFD YMSPDRSKRQ
     QDENMTDVGL IPQDQTEQSE YPELDFIDLL DIDSNATPLI DENMLFNDEE SDDIQGSMIS
     MQNNIIKQSK IGRNFDLEEV KEEMSEESMR QQKSQHTDKI SDHRNSSIGI RKSGTEQDQT
     EFQPRYILKG DKIIRVRAAR EKQPQDYPHL NAHFSEKKDL LEHLIQLRQV RQNRNLQLKD
     TKIFITEKNK YEIKVDEKVN INTVGNYIEH VTNQPLRYNK LAPTSKQINK KYQSQGDKDK
     YQRHLIQDTD KKADIDQKLK QEAKRDLIIQ NMGSAENRFI TPATQYNIDS QNNMGGFEKQ
     RQVLNNEQQQ TSQMQTLFDL HQKFDLINGI TQMIIEVFVQ TREGCAVFYV IHNECAELDL
     EDKYNKIHGV IVNKQASKSI KSINMGTHMQ INESIFAKNE VNLFQKVIDI FRYYDPDIVT
     GYETEAMSIG YICKRAEKIG IQMSSVLSRT PMTLKPLNES FYNQKLLKEQ RLRSVDDQDD
     IQEAYKQQKD QREDKKKMSY FYNKFGQAIK LNGRIIINLW TILRHEINLT NYDLENVCFN
     ILKKREPRYD YDTQSQWWMK GQFYNVASYQ FKRLLNIYSI LETMDLINRD INMAKVYGID
     YESVMTRGSQ FRVEAILSRI TKSQDYLLLS AAVQQVRNQN ELEVIPLVVE PDKLFYTSPV
     IIVDFQSLYP SVIIAYNLCY STCLGKIIQI NPENNTDQRK LGVYVIPGNI KSFFGIENDQ
     DLTPEQEQYI LDNIIIAPNL NCFVKPHLRL GLLPRMLREI LYTRIMVKKS MKLYQPGSIT
     YRMLDSRQLA LKLIANVTYG YTAAGFSGRM PCSELADSVV AIGRHTLERC MKIVNQNEET
     WGTRVVYGDT DSTFILCEGR TLEDTFRIGE IIAKTMTEIN PFPMELKLEK VYYPCVTLAK
     KRYCGYKMEK ITDTPVLDAK GIETIRRDTV EAVAKIMDKC LRLLFETKDL TQIKSYLIKQ
     WTKIQNGDVE FKDFIFAKEV RLGTYRVLPP SAIICERRLE RDPGAMPRYK ERIPYVIAMG
     QGGAIDQSKI KDLVLSPEEF LSSDGLLLNA NYYIRRQINA ALNRIFLEIF DIDVNQWFNR
     MPKLNREQGI HSKKIDYFQQ QISSSRSNIS KSKLSSKLSS RSGVSSTSIA GQNSMMIDQF
     YQRKNCIVCG DESKQKLCKT CTKNVRETIY ILNQRLKNLQ NQLEKNNMIC LACSNMLLRG
     RVAQLVQAMP NDGISDEVVP CLNYQCRIFY EKMAFNKEYA YLKDAIEKIN INQI
//
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