ID A0A078A0N2_STYLE Unreviewed; 734 AA.
AC A0A078A0N2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 28-JUN-2023, entry version 35.
DE SubName: Full=Atp-dependent dna helicase {ECO:0000313|EMBL:CDW74323.1};
GN Name=Contig3961.g4240 {ECO:0000313|EMBL:CDW74323.1};
GN ORFNames=STYLEM_3318 {ECO:0000313|EMBL:CDW74323.1};
OS Stylonychia lemnae (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW74323.1, ECO:0000313|Proteomes:UP000039865};
RN [1] {ECO:0000313|EMBL:CDW74323.1, ECO:0000313|Proteomes:UP000039865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=130c {ECO:0000313|EMBL:CDW74323.1,
RC ECO:0000313|Proteomes:UP000039865};
RA Swart Estienne;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
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DR EMBL; CCKQ01003213; CDW74323.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A078A0N2; -.
DR EnsemblProtists; CDW74323; CDW74323; STYLEM_3318.
DR InParanoid; A0A078A0N2; -.
DR OMA; WAMQYVW; -.
DR OrthoDB; 178937at2759; -.
DR Proteomes; UP000039865; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CDW74323.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000039865}.
FT DOMAIN 294..438
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 165..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 545..575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 174..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 85228 MW; 874183BF9A3D4CB8 CRC64;
MNKLFGGDNT KQTRFQVAKE SVKMLIESKL LYATSHEIGI VLIGTQKSSN FLNDQYEDQY
KHVTTFRQID KLDLESFRHL ENITCEKAPI KDNGGDLLDG LIVGMDMMVR HCGEKKYKKR
VFLITDGERE TKYDPRELKQ IITTLNERDT RLNIITLDFC NELAEDDEDD DEEESKKDSK
KKESAADETE SQNKNKEFLM ELTDKVKGAI FPAKVAMEIY KQFKKREVMA RVKYRGNLDL
AKDLKLNVSI YSRTREEVFP SLKKHSTIAN ESTSAKESLV KLERQFAEVD DPDQQPVDTD
QQIKAYNYGK QLVPVSKENE HILKYKPPKQ DDEHDPANDM DVKVQNQSKV PRHHFIAGVD
VILPVKGSKN ERAFAALVFA MIETHRVLIA RIVERKNVDP KLVVLYPHIS KKKPLLYMAQ
IPTNEEIRDY QFPSLIPATK PQKTAAKQLI KALDLVDQEA EEEKLKPEIT FNPALQYFSQ
VVVHRITEPA QQELPQLNQQ IAEYVKPDKK LFQQAEDEIS AFEEAFELKY NNEDENKKKK
RVYWRDIIRK EEEKVANEEQ KLEEEEQIAR QKIGDKDMDD KEDKIKEISS MNPIEDFKNM
VNDRKVDRVS DAIDQMQKLI IRFVTNSLAG DLYSRALDCL IALRESCINE DEGQKFNQFM
EKLKQLFSKG TNKEFFQSII KHKISLITKD ESSISSVITA DEAKRFLEID KDDSGQMAQQ
KKIKQEDEFM DEIE
//
