ID   A0A078A485_STYLE        Unreviewed;       727 AA.
AC   A0A078A485;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:CDW76967.1};
GN   Name=Contig7694.g8204 {ECO:0000313|EMBL:CDW76967.1};
GN   ORFNames=STYLEM_5932 {ECO:0000313|EMBL:CDW76967.1};
OS   Stylonychia lemnae (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX   NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW76967.1, ECO:0000313|Proteomes:UP000039865};
RN   [1] {ECO:0000313|EMBL:CDW76967.1, ECO:0000313|Proteomes:UP000039865}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=130c {ECO:0000313|EMBL:CDW76967.1,
RC   ECO:0000313|Proteomes:UP000039865};
RA   Swart Estienne;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CCKQ01005710; CDW76967.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A078A485; -.
DR   EnsemblProtists; CDW76967; CDW76967; STYLEM_5932.
DR   InParanoid; A0A078A485; -.
DR   OrthoDB; 180294at2759; -.
DR   Proteomes; UP000039865; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF435; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG; 1.
DR   PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000039865};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        286..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        339..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          524..634
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          60..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          672..709
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        60..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  86171 MW;  A6BF09F2199E13D8 CRC64;
     MGDASNYLLS VTDQNLHDQS FADYNTRDIP PKNLFNQNNH KVKVVKTAAM EVDEADYNTS
     TNIPLTKQNT KNQDSTQNTF DVTSPSKRKK SKKDVFGIVT LEDENKQSQN SQRRFSMRKG
     DSRVSELENS EFDRSEQKQR PFLDSAAFGL ETSAINEGFN IAVEVLFGVD IILKYISEED
     FYPVRDIKKI AIRYLKRSFI FDMLSVIPFR YFIKDAETRQ LCSLFKILRL PKLFLLLDSR
     NFKHIIKTYY DNKLQRVLKN VDMKHDQLQD NNNIMLQIMI NYAFKVLRLI IVIFSISYFI
     GTLWYIFTWQ IDDPNDDTPN SNFFKTYGMR ELKKNNDDIN SMIIVVYFAF TTLATVGYGD
     YHAVSDSERV VCSIILLFGV AVFSFIMGNF IEILMSFKIV TAQNEESENL TKWLGLLARF
     NKGRPLPKEM IRKIENYFDY YWAQDRNYAL KSQDDLRFMQ ELPKQIRINI FREFLFKNFL
     YQFRSYFTIE RDPSELNDSM SLEDSKVQKL KFYNWNDTQY AQFMMNIMQN LEPRKYQRND
     LILYDLEEVD EVIYVCSGQY GVGYQLNNQE YIAVKIGQKS VIGDHSVVFR KRSEFMYRAL
     GEMDCYGLRK NRLYTIFDKY KEFSAKMKKN ISSRYQDVIR KNVLEHKQKT IEKIKRIYKI
     EYSLWMYVSN PLDEEKELKK EMENKAGEGQ AAMRRVKKLE QKVEKLGNSV YQLFKKYDNQ
     LQELMTI
//