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Database: UniProt
Entry: A0A078F373_BRANA
LinkDB: A0A078F373_BRANA
Original site: A0A078F373_BRANA 
ID   A0A078F373_BRANA        Unreviewed;      1824 AA.
AC   A0A078F373;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-JUN-2019, entry version 26.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=BnaA07g24980D {ECO:0000313|EMBL:CDY07419.1};
GN   ORFNames=GSBRNA2T00124409001 {ECO:0000313|EMBL:CDY07419.1};
OS   Brassica napus (Rape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae;
OC   Brassica.
OX   NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY07419.1, ECO:0000313|Proteomes:UP000028999};
RN   [1] {ECO:0000313|EMBL:CDY07419.1, ECO:0000313|Proteomes:UP000028999}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999};
RX   PubMed=25146293; DOI=10.1126/science.1253435;
RA   Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X.,
RA   Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C.,
RA   Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P.,
RA   Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H.,
RA   Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H.,
RA   Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G.,
RA   Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H.,
RA   Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J.,
RA   Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A.,
RA   Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D.,
RA   Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J.,
RA   Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J.,
RA   Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G.,
RA   Paterson A.H., Guan C., Wincker P.;
RT   "Plant genetics. Early allopolyploid evolution in the post-Neolithic
RT   Brassica napus oilseed genome.";
RL   Science 345:950-953(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; LK031978; CDY07419.1; -; Genomic_DNA.
DR   EnsemblPlants; CDY07419; CDY07419; GSBRNA2T00124409001.
DR   Gramene; CDY07419; CDY07419; GSBRNA2T00124409001.
DR   OMA; HESHVPY; -.
DR   Proteomes; UP000028999; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028999};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028999};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       55    199       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      966   1163       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1231   1678       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1724   1796       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      509    540       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A078F373}.
FT   REGION     1088   1110       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A078F373}.
FT   COMPBIAS   1088   1107       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A078F373}.
SQ   SEQUENCE   1824 AA;  202289 MW;  4B10A201576FDBC3 CRC64;
     MAESLSGPNV FSLRIVSIDY YMASPIPAYD LCYNSFQGGE VKEVPVIRVY GSTPSGQKTC
     LHIHRALPYL YIPCSDIPLD QHNGVDGIIP TISLELEKAL KLKGSAASKR QHVHDCEIVR
     AKKFYGYHST EEAFVKIHLY HPQDVSRAAS LLLAGAVLGR SLQPYESHIP FILQFLVDYN
     LYGMGHVHIS KMKFRSPVPH QFHPRKFDLD DCVGQGIDEM ASTKADSSAA ANVSFPVWSL
     STIPGQWMWN LSEESDTPLS QSQHSHQYRR QSLCELEGDA TISDILNQQL KMYNSLSQAQ
     SDTKMVQSLV AIWEEEYERT GVYDAPIHHD PGKPSAADVL KTMSHYIGFE NMLKEMYHEV
     GMPSPDTKAT AVSSAVSEMH AKPEITDPQA LGHIFGTGSE FPASEKLSPL DESGEASLEN
     DAYMKTPTDI DIHAEIQDAE ALGLFKWFAS SQAAEDINSD DEILRETILS PLVPLASMNK
     VLEMASTDYL SQSQKECQDI LDSQEDQIDL GSSTKPVPSS DKQSIDTEVS SDVPNISTSD
     ASYENSFQRY RKSELHTTFS RSSKSVWGPL PLSLTKNLQK DFDSTNASDK LGLPKISSDA
     TNEMKDNFDV PVKEHQADVC NTIDGSVLAG YSLRDLMRKK RLALGDSPGS QHKKFKKVLP
     LTTVTRDSGD GKKKECSATL SAEVSDAGNC EFNISTQSSE LHSADRCSAK ETAAEDSDEA
     SRKFSSASAP LCKESQTVES GILVSSNKLV GNDINNVQKS GDEQELTANV AVETGRLICL
     TLSKKPPSLD CLSAGLQDSS RDGYEGSSKE ISFFSKEDTE VNEKKHLSKG ASLGIPMHHL
     NDGSSLYLLT PAFSPPPLDS VSQWISNNKG PVDSSIASEK QTLGDDHVMS VSEHVEQHDN
     VFVNSESNAY TESEIDLKSK GKNPNLNLQT TVSQEMSQLS GPDGKSGATP LSQIGFRDPA
     SMGAGKQLTV LSIEVHAESR GDLRPDPQFD SVNVIALVVQ NDDNFAAEVF VLLFSPDIVS
     QRNVDGLSGC KLSVFLEERQ LFRYFIETLC KWDPDILVGW DIQGGSLGFL AERAAQLGIR
     FLNNISRTPT PTTRNDSDNT RNLGNSLQPD PLVAGPDQVE EVVIEDEWGR THASGVHVGG
     RIVLNAWRLI RGEVKLNMYT IEAVSEAVLR RKIPSIPYEV LTQWFSSGPA GARYRCIEYV
     IRRANLTLEI MSQLDMINRT SELARVFGID FFSVLSRGSQ YRVESMLLRL AHTQNYLAIS
     PGNQQVASQP AMQCVPLVME PESAFYDDPV IVLDFQSLYP SMIIAYNLCF CTCLGKLAHL
     KMNTLGVSSY SLDLDVLQDF SQILQTPNGV MYESPEVRRG ILPRLLEEIL STRIMVKKAM
     KKLTPSEAVL GRIFNARQLA LKLIANVTYG YTAAGFSGRM PCAELADSIV QCGRSTLEKA
     ISFVNANENW NARVVYGDTD SMFVLLKGRT VKEAFEIGQE IASGITEMNP YPVTLKMEKV
     YQPCFLLTKK RYVGYSYESP DQDKPTFDAK GIETVRRDTC EAVAKTMEQS LRLFFEKKNI
     SMVKSYLYRQ WKRILQGRVS LQDFVFAKEV RLGTYSARDS SLLPPAAIVA TKAMRADPRT
     EPRYAERVPY VVIHGEPGAR LVDMVVDPLV LLDIDSPYRL NDLYYISKQI IPALQRVFGL
     VGADLNQWFL EMPRPTRSSL GQRPLNSRNS HKARIDYFYL SKHCLLCGEV VQDSAQLCNR
     CLKNGGAAAT IVWKTSKLER EMQHLATICR HCGGGDWVVQ CGVKCNSLAC SVFYERRKVQ
     KELRGLSSIA TESELYPKCM AEWF
//
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