ID A0A078GZ08_BRANA Unreviewed; 595 AA.
AC A0A078GZ08;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN Name=BnaA04g25580D {ECO:0000313|EMBL:CDY30457.1};
GN ORFNames=DARMORV10_A04P33220.1 {ECO:0000313|EMBL:CAF2301780.1},
GN GSBRNA2T00045161001 {ECO:0000313|EMBL:CDY30457.1};
OS Brassica napus (Rape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY30457.1, ECO:0000313|Proteomes:UP000028999};
RN [1] {ECO:0000313|EMBL:CDY30457.1, ECO:0000313|Proteomes:UP000028999}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999};
RX PubMed=25146293; DOI=10.1126/science.1253435;
RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., Chiquet J.,
RA Belcram H., Tong C., Samans B., Correa M., Da Silva C., Just J.,
RA Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., Noel B.,
RA Labadie K., Alberti A., Charles M., Arnaud D., Guo H., Daviaud C.,
RA Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., Tack D.,
RA Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., Renault V.,
RA Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., Chalabi S., Hu Q.,
RA Fan C., Tollenaere R., Lu Y., Battail C., Shen J., Sidebottom C.H.,
RA Wang X., Canaguier A., Chauveau A., Berard A., Deniot G., Guan M., Liu Z.,
RA Sun F., Lim Y.P., Lyons E., Town C.D., Bancroft I., Wang X., Meng J.,
RA Ma J., Pires J.C., King G.J., Brunel D., Delourme R., Renard M., Aury J.M.,
RA Adams K.L., Batley J., Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W.,
RA Sharpe A.G., Paterson A.H., Guan C., Wincker P.;
RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic
RT Brassica napus oilseed genome.";
RL Science 345:950-953(2014).
RN [2] {ECO:0000313|EMBL:CDY30457.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAF2301780.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope - CEA;
RA William W.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU003862};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743, ECO:0000256|RuleBase:RU003862}.
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DR EMBL; HG994358; CAF2301780.1; -; Genomic_DNA.
DR EMBL; LK032253; CDY30457.1; -; Genomic_DNA.
DR RefSeq; XP_013725459.1; XM_013870005.1.
DR STRING; 3708.A0A078GZ08; -.
DR PaxDb; 3708-A0A078GZ08; -.
DR EnsemblPlants; CDY30457; CDY30457; GSBRNA2T00045161001.
DR GeneID; 106429264; -.
DR Gramene; CDY30457; CDY30457; GSBRNA2T00045161001.
DR KEGG; bna:106429264; -.
DR OMA; IGWDEFP; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000028999; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IBA:GO_Central.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IBA:GO_Central.
DR GO; GO:0009086; P:methionine biosynthetic process; IBA:GO_Central.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IBA:GO_Central.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF7; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003862};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003862};
KW Reference proteome {ECO:0000313|Proteomes:UP000028999}.
SQ SEQUENCE 595 AA; 67035 MW; DB8317B59C99FBE2 CRC64;
MKVIDKIKSW TDEGKTTFSF EFFPPRTEDG VDNLFERMDR LVAYGPAFCD ITWGAGGSTA
DLTLDIVSRM QNVVCVESMM HLTCTNMPVE KIDHALETIR SNGIQNVLAL RGDPPHGENK
FVQVEGGFGC ALDLVNHIRS KYGDYFGIAV AGYPEAHPDV IGENGLASKE AYQSDLEYLK
KKVDAGADLI VTQLFFDTDM LLKFVNDCRQ IGIKCPIVPG IMPINNYKGF LRMIGFCKTK
IPAEVMAALE PIQDNEEAVK AYGIHLGTEM CKKILAHGIK SLHLYTLNME KSALSILMNL
GMIEESKISR SLPWRRPANV FRIKEDVRPI FWANRPKSYI SRTKAWENFP QGRWGDSRSA
SYGALTDHQF SRPRARDKKL QQEWVVPLKS VEDIHEKFKE LCLGNLKSSP WSELDGLQPE
TKIINEQLVK VNSKGFLTIN SQPSVNAERS DSSTVGWGGP GGYVYQKAYL EFFCSKDKLD
ALVEICKALP SITYIAMNKG ETWVSNTSQS DVNAVTWGVF PAKEIIQPTI VDPSSFNVWK
DEAFETWSRN WANLYPEEAD PSRNLLEDVK NSYYLVSLVE NDYINGNIFK VFSDL
//