ID   A0A078KTY2_9FIRM        Unreviewed;      1180 AA.
AC   A0A078KTY2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=CCDG5_1479 {ECO:0000313|EMBL:CDZ24589.1};
OS   [Clostridium] cellulosi.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Oscillospiraceae incertae sedis.
OX   NCBI_TaxID=29343 {ECO:0000313|EMBL:CDZ24589.1, ECO:0000313|Proteomes:UP000032431};
RN   [1] {ECO:0000313|Proteomes:UP000032431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG5 {ECO:0000313|Proteomes:UP000032431};
RA   Wibberg D.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; LM995447; CDZ24589.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A078KTY2; -.
DR   STRING; 29343.CCDG5_1479; -.
DR   KEGG; ccel:CCDG5_1479; -.
DR   PATRIC; fig|29343.3.peg.1560; -.
DR   HOGENOM; CLU_001114_3_1_9; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000032431; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 2.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014152; AddA.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR02785; addA_Gpos; 1.
DR   PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000032431}.
FT   DOMAIN          3..472
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          484..775
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         24..31
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1180 AA;  132255 MW;  59BA0C1FFDF3B343 CRC64;
     MERKWTSEQR DAIYARGGTL LVSAAAGSGK TAVLVERVIG LITDPNHPCD ADRLLVVTFT
     NAAAAEMRER ISQRLSDMIS QNPLDFNLQR QQMLLQNGHI STIHSFCLDL LREHFEKLDI
     PPDFRVADQN ESEIIRSEVL SDILEKMYAE GGEAFLELSR VLSTGRGDKA LSDTVLRLYD
     FMRSLDDADG FLKSAAAMYD ETKPVENSVW GRIAIEYTKA ALGSALNAHR RALLKIHGDP
     QLDKAYGPAF ESDIAGIERL IEKAESGDWD GLCSAVSGFS FERLGALRKF GDEALKEELK
     AQRDSLKKLL SELSSGVLCS SAADFKSDMR RLRPLVECMC DILKKLDREF FKEKLSRGIL
     DFSDLEQLTL KLLIKREDGK AVFTNTAREI ASRFDEILVD EYQDTNPAQD MIFRAVSRNE
     TNLFMVGDVK QSIYSFRQAR PELFTGMSER CTPFDGVNFP ARIILGRNFR SRKGVTDAVN
     FTFEKLMSKE LGGVDYGENE KLTPAATYFE RGGADFAIHL IDAGEYDGDE DGAEIEARHI
     AREIKRLIAE GFTVQGEKGP RKVTYRDFSI LLRSMEGRAQ KYVRVLENEG IPVYADIASG
     YLGAYEVMVA LSLLRIIDNP LQDVPLVSVL LSPVFGFTPD DIALVRLKAK DKSLYLALLE
     FAKEDNRFDG FLSLLDRLRT LAAVLPADRL ILRIYDETGM LNIFEAMPNG EMRHANLRLL
     LDYARAYESA GWRGLSGFMN FIDRVDRQNS DIAPASSISE NADVVRIMSI HKSKGLEFPI
     CFLGGLSKRF NNEDIQKPVL FHPYCGLGSM VRDNRLNCRF TTLPREAARI EIQKSSLSEE
     MRVLYVAMTR AKEKLYAVMT LKNAETALRR AASIMRSGEK VSYFEAMSAQ CPAELLLAAA
     LVHPSCGKLR SLAGVYDAPV KDSGGIWEFE WIDARSLVSA DSANEKADNE IYKTAETERL
     KNEIKARIEY KYPYENLLKL PTKVSVSELT EKQGTDFSAE NVRPSFLEGE GLSPAEKGTA
     LHAFMQYCRL DALRSESGAA EEVERLVEEK FILPEQGAAV DTAKAAAFGS SPVYKRICAA
     KKLWREFRFN IEVPANEIYE EAADTDAKIL LQGMADLVFE EDGGAVILDY KTDRVSSPEA
     LIERYSGQLN SYARAVQEIL GVPVKEKIIY SFQLEREIRV
//