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Database: UniProt
Entry: A0A078L642_9CHLA
LinkDB: A0A078L642_9CHLA
Original site: A0A078L642_9CHLA 
ID   A0A078L642_9CHLA        Unreviewed;       456 AA.
AC   A0A078L642;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   10-APR-2019, entry version 16.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   Name=tuaD {ECO:0000313|EMBL:CDZ80591.1};
GN   ORFNames=BN1013_01106 {ECO:0000313|EMBL:CDZ80591.1};
OS   Candidatus Rubidus massiliensis.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Candidatus Rubidus.
OX   NCBI_TaxID=1444712 {ECO:0000313|EMBL:CDZ80591.1, ECO:0000313|Proteomes:UP000039860};
RN   [1] {ECO:0000313|EMBL:CDZ80591.1, ECO:0000313|Proteomes:UP000039860}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Urmite Genomes Urmite Genomes;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CCSC01000001; CDZ80591.1; -; Genomic_DNA.
DR   STRING; 1444712.BN1013_01106; -.
DR   EnsemblBacteria; CDZ80591; CDZ80591; BN1013_01106.
DR   Proteomes; UP000039860; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000039860};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000039860}.
FT   DOMAIN      322    426       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    266    266       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     158    158       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     269    269       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     336    336       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   456 AA;  50620 MW;  F6BBAD205C052C41 CRC64;
     MDILVIGTGY VGLVTGTCLA EMGHHVTCLD IDEQKIEKLL NGTIPIYEPG LEEMVKRNSK
     ADRLYFTTDY ETALQEAEVC FITVDTPVSP TGHANLDFVK AVAKSIGLYI NNYKVIVNKS
     TVPVGTAHLV KEIIQAEIEA KKQNILFDVV SNPEFLKEGN AVNDCMKPDR IIIGTDSPKA
     AAIMKKLYSP FMLNHEKFML MNIASAELTK YAANAMLGLR ISFMNEMANI CERTGADINE
     IRKGIGSDKR IGSDFLYAGA GFGGSCLPKD IRSLVKQAEE LNSSSAILQA IEEVNSNQKK
     VLGEKISRYF SLCDGLKNKT IAILGLSFKP DTDDMREAPS LTLINQLLEE GATVRLYDPV
     AMDNAKKIIP DNENIVWCEN ELEAAFGAHA IALVTEWKQF RFLDFEAILH NMEGCAFFDG
     RNQYIPLEMY QKGFDYFSIG TSFAQQSLTP EYNFVS
//
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