ID A0A078LYX3_9STAP Unreviewed; 1151 AA.
AC A0A078LYX3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=addA {ECO:0000313|EMBL:CDZ99170.1};
GN ORFNames=BN1048_00295 {ECO:0000313|EMBL:CDZ99170.1};
OS Jeotgalicoccus saudimassiliensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Jeotgalicoccus.
OX NCBI_TaxID=1461582 {ECO:0000313|EMBL:CDZ99170.1, ECO:0000313|Proteomes:UP000044136};
RN [1] {ECO:0000313|EMBL:CDZ99170.1, ECO:0000313|Proteomes:UP000044136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13MG44_air {ECO:0000313|EMBL:CDZ99170.1,
RC ECO:0000313|Proteomes:UP000044136};
RA Urmite Genomes Urmite Genomes;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CCSE01000001; CDZ99170.1; -; Genomic_DNA.
DR RefSeq; WP_035807652.1; NZ_CCSE01000001.1.
DR AlphaFoldDB; A0A078LYX3; -.
DR STRING; 1461582.BN1048_00295; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_3_1_9; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000044136; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000044136}.
FT DOMAIN 2..463
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 475..756
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 216..250
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1151 AA; 131872 MW; F15F3F9050EE012C CRC64;
MVKFTEAQSM AINTKGSDIL VSAAAGSGKT AVLVERIKQN IIDGNYSIDE VFVSTFTNKS
AKDMKDKIER ALRQTYNETP DPRLNDEIIK LNDAHISTLH SFCLYLIQTH YNAVGLPPDM
RTLGQVETEI RLQNIITAVL EEFYIAADED FLKLDQFVTS NKDNSALHKL VTQLYHVAIA
TKEPMNFLNG MTDQYITDQK LEEILGSYRA VIGRRLRKLD QDLYILKTEY DNAERDEELK
EKAIDDAYEK LAVMHKYVTG ALESFSTEGS FKLPAAKLVT GANAFIKSAT AYGNDLNDRY
NKPANTLYQE LSKVTQYTHE DVKAELAPLN GMNNQLINIA KEVIEAYRKD KQSANEMDFN
DYEHYALDIL TANDNEIAER YKEQFKEIMI DEYQDINRVQ EAIIQLLKSG DEHDGNLFMV
GDVKQSIYRF RQAAPDLFID KSERFNHADS GRLIQLNRNF RSRSEILDAT NLIFENIMDK
NLGEIEYTDE EKLIKGIEAA EPESPVEVLP VIYDKNLKSA DADELEIKQI VKLVQELYKK
GASYQDIVIL NRNRFAPDIM RHEFQKADIP ISIDVNKGYF ETFEILTMRS ILSLIDNPLQ
DDHLAGVMRL PMFGFSEEEI AEIRISSDEK YLYEALTEYS GKEQIMRKIE EFTGTFKELK
LHAKYLSVPE LIAEIFFELN ILEFFSGLPG GSARRANLNG LIDRALEFQS MNNTSLYQFI
SYIDFLISEG KDFGEEGPLE NTDDAVRVMT VHSSKGLEFK HVIYADLKQN FTLTKVTRVY
VHPKLGIVFN NFNDELNYHY DSIHGFTAND FLTIEQLSEE LRLIYVALTR AEEKLYLPLM
FKGEEEYKYD FSRMEKPSFE TRAELKSAMD FLAPVLMQSS APFIEVKEAE ITDGEENERT
EYAGLSDIDA LNADIIPEVR ERLFYNYPNQ DDAEVTTKES VTSIKRRNET IPDGAEYISH
TSEVKLREPN FLGDSLEAPV FGTIMHEMMM HIMHQWQTLS VMDEAARTAY IDTLIDNYSA
NYELLSSVHI KKMKENAARF FNDEMMNGLL NTQKGIHTEL PFIMSQEAIG YAEHPEQIVQ
GIIDCLLEYD DRYIIIDYKT DRVKGTDLTA SDLAGRYSTQ MDIYTKSAQV SLGKPVTAVL
YFFDYGAIPV E
//
