ID A0A080M0Q9_9PROT Unreviewed; 429 AA.
AC A0A080M0Q9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Macrolide-specific efflux protein MacA {ECO:0000313|EMBL:KFB74788.1};
GN Name=macA_4 {ECO:0000313|EMBL:KFB74788.1};
GN ORFNames=AW06_004258 {ECO:0000313|EMBL:KFB74788.1};
OS Candidatus Accumulibacter cognatus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=2954383 {ECO:0000313|EMBL:KFB74788.1, ECO:0000313|Proteomes:UP000021315};
RN [1] {ECO:0000313|EMBL:KFB74788.1, ECO:0000313|Proteomes:UP000021315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-02 {ECO:0000313|Proteomes:UP000021315};
RA Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT clades.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFB74788.1}.
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DR EMBL; JDST02000130; KFB74788.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A080M0Q9; -.
DR STRING; 1453999.AW06_004258; -.
DR Proteomes; UP000021315; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 2.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 2.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF16; HAE1 FAMILY EFFLUX PUMP MFP COMPONENT; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000021315};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..131
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 209..333
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 131..165
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 429 AA; 44951 MW; 0BD7352A6908536A CRC64;
MAEPDKTPAS PLSLLAIDRN AAPTRRRRRR WAVWLAAVLG IGGIAAYLLV PGRVDVQVTT
VLSAYPSQQY TQLTASGYVV AQRRASVASK GTGRLVELRV REGSPVQAGE LIGRLDASDV
RAALRVAEAA IGQAAAGLRQ AEANLEQARA EAANAEVEFQ RQQALRARGF VSSQAVDAAQ
RRALAARAGV GAGRAAIDSA RAAVALAQAQ VAVQQVNQDN TDIRAPFDGV VLVKNANVGD
MITPFSAAAG TSGAVVTMAD MSTLEVEADV SESHVARVRV DMPVEITLDA IPDARFRGSV
ARVVPTVDRA KATVVTKIRF DRIDARILPE MSAKVNFLSQ PATDADQTPV VAVNPRAIAE
RAGSKVVFRL LGETVEALPV TLGRKLGDAQ ELTGSPLQPG ERLVLAPPER LAAGAQVVVS
GGSAAKRSP
//
