ID   A0A080WWD1_TRIRC        Unreviewed;       287 AA.
AC   A0A080WWD1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit {ECO:0000313|EMBL:KFL62388.1};
GN   ORFNames=TERG_06560 {ECO:0000313|EMBL:KFL62388.1};
OS   Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559305 {ECO:0000313|EMBL:KFL62388.1, ECO:0000313|Proteomes:UP000008864};
RN   [1] {ECO:0000313|Proteomes:UP000008864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; GG700655; KFL62388.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A080WWD1; -.
DR   VEuPathDB; FungiDB:TERG_06560; -.
DR   HOGENOM; CLU_970404_0_0_1; -.
DR   OrthoDB; 166915at2759; -.
DR   Proteomes; UP000008864; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:KFL62388.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008864}.
FT   DOMAIN          106..263
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   287 AA;  31910 MW;  4B822399B1D27399 CRC64;
     MFSRLIRARG VAQVGRQPST QLFRRSVTTD AASAHAEDIP VVRLPGLPIE RIYAGRKSAN
     HSFARLQEDD KPFSVKLSDE SFETYELDPP PYTLKTTKKE LKQMYYDMVS IRRMEMAADR
     LYKEKKIRGF CHLSTGQEAV ATGIEHAITP DDKLITAYRC HGFAMMRGGT VRSIIGELLG
     RREGIAYGKG GSMHMFAKNF FGGNGIVGAQ VPVGAGLAFA QQYNGEANTT VCLYGDGASN
     QGQVFEAFNM AKLWNLPVMF GCESTFQIVF YPFFSMLCCG RINTFDL
//