ID   A0A081BSC4_9BACT        Unreviewed;       430 AA.
AC   A0A081BSC4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=O-acetyl-L-homoserine sulfhydrolase / O-acetyl-L-serine sulfhydrolase {ECO:0000313|EMBL:GAK54305.1};
GN   ORFNames=U14_05585 {ECO:0000313|EMBL:GAK54305.1};
OS   Candidatus Moduliflexus flocculans.
OC   Bacteria; Candidatus Moduliflexota; Candidatus Moduliflexia;
OC   Candidatus Moduliflexales; Candidatus Moduliflexaceae.
OX   NCBI_TaxID=1499966 {ECO:0000313|EMBL:GAK54305.1};
RN   [1] {ECO:0000313|EMBL:GAK54305.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sekiguchi Y., Ohashi A., Parks D.H., Yamauchi T., Tyson G.W.,
RA   Hugenholtz P.;
RT   "First genomic representation of candidate bacterial phylum KSB3 points to
RT   enhanced environmental sensing as a trigger of wastewater bulking.";
RL   PeerJ 3:e740-e740(2015).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; DF820461; GAK54305.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A081BSC4; -.
DR   STRING; 1499966.U14_05585; -.
DR   HOGENOM; CLU_018986_4_0_0; -.
DR   Proteomes; UP000030700; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:GAK54305.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030700}.
FT   MOD_RES         210
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   430 AA;  46426 MW;  248799C9F0A122AA CRC64;
     MSKLDQQLHL ETLALHGGQE ADPTTGSRAV PIYQTTSYLF KDSDHAARLF GLQEFGNIYT
     RLMNPTTDVL ERRIALLDGG VGALAVASGQ SAITLALLNI ARAGDEIVSA DNLYGGTYTL
     FHYTFARLGI TVNFVSSDDL DAFRKVITPK TKAIYAESIG NPKLNVADLE ALAQIAHDNG
     IPLVVDNTVA PYLLRPIDFG ADIIVYSATK FIGGHGTSIG GLIVDSGKFD WTNGKFPLIA
     DPDPSYHGIN FVEALKPLGN IAYITKARVT LLRDLGPALS PFNAFQFLQG LETLHLRMPR
     HCENALAVAK FLQTHPKVQW VNYPGLENSP EQARVKKYLP NGAGAILGFG IKGGLDAGKK
     FIDSLRLVSH LANIGDAKTL AIHPASTTHQ QLSPEEQLAT GVTPDFIRLS IGIEHIDDIV
     ADLKQALDQA
//