ID A0A081CNT3_PSEA2 Unreviewed; 1249 AA.
AC A0A081CNT3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=PAN0_068d6574 {ECO:0000313|EMBL:GAK68329.1};
OS Pseudozyma antarctica (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=84753 {ECO:0000313|EMBL:GAK68329.1};
RN [1] {ECO:0000313|EMBL:GAK68329.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 10317 {ECO:0000313|EMBL:GAK68329.1};
RA Morita T., Saika A., Koike H.;
RT "Draft genome sequence of the yeast Pseudozyma antarctica JCM 10317 known
RT as a producer of lipase B which used in a wide range of industrial
RT applications.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; DF830135; GAK68329.1; -; Genomic_DNA.
DR RefSeq; XP_014653477.1; XM_014797991.1.
DR AlphaFoldDB; A0A081CNT3; -.
DR GeneID; 26307375; -.
DR HOGENOM; CLU_003181_2_0_1; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000053758; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR013183; Hsk3-like.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF08227; DASH_Hsk3; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000053758};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 528..549
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 633..664
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 714..737
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 788..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 829..849
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 885..906
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 912..931
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 952..973
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 979..1003
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 1190..1247
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 87..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 134656 MW; BA19A95A40B98E8F CRC64;
MLAITTTTTT TLTLAAGIMN PHIPSGATSS ATLSNKEKHY AQLAAKLGAL ATTFDTTKQH
LNLAAEQAFY MRKLGIAQAS TTGELQGLAG VNPAEPPSRA TNTAPVQQPN ARLHARTHHL
SQQLHFSILP PSSPPPSAST AIVSSATPMA DPKRAASASR SPSRAQPNSG LTVSTRPPAA
DTANDHVEHR NAHQSAPSSA RPRLAGRRTM SSKSDTRRLS SLFVPPTSDA QQTTDNAAQP
HSSSRLAALS KGISGALSGS ASIASLREPL SPIRSFYGGL TGQAIPGSRK RSKQDFRSYD
DATFEDEMNL PGSGGNGVRV WYESYTTIDW IHDAIKESSR LRRIRNLRGI RGLAINSWDR
LQGWIIVTIT GIVTALIAGC IVKSEAVLFD LKDGYCARDW RLAKRFCCPY GNAPDWDHPD
IASASTSAAW SYRTRFLPNA AIPTSPADAL QSLVSGVGVG NRILSGWAAP VAGSPAWHRQ
PSFPSPHANA SLSAMLSPVD SETEDCPGWI SWGQKFGSAA THNWAASYSM YFVVAILWAS
IASILTIYLT SSELYLKDPA TNSSATANLN QNQKPSSDAR HHPNNLDQEP TETSALLPTA
SSDANRPDRL HSRDFARRAN DQRASKAILP RKVLYFATGS GISEVKCILS GFVIHGYLGF
WTLFTKSVGL TLSVASGLSL GKEGPFVHIA SCVGNIVCRI FPKYENNEGK RREMLSCACA
AGVAVAFGAP VGGVLFSLEE VSYYFPSKVM FRSFFCAMVA AATLRAIDPF GTGKIVLFQV
TYDKDWHFYE MLFFVLIGIF GGLYGAYFTK LNMFWAKNVR AKTWMARHPI LEVVFITVAT
AALSFFNGYT RMGGVELIAD LFSECHEHES LEGLCVSQPS QIKPLILSIL FAMALKGLLT
VVTFGIKLPA GIFIPTLAVG ACFGRIVGLL VQYVQWTHPE LGFFSWCPAS DSACIVPGVY
AMVGAAAALS GVTRTTVSLA VIMFELTGTL TYSVPVMLSI LVAKTIADAL EHKGIYDLVI
EFSGLPYLDS KTEYIWNGVN VTDAMETEVE VICLDAFNSL QSLADKLDRL AQGSGYTDGG
FPIVSRVAAA ASSAIPASPL LSASLGSLTD AAAPSSGSDS AYQMVGYIAA SELEHALTRA
VRADVDMRPE VTRCSFNNIP FVRAENEGEA NVRDSVLFTA SDPLDLSRYV DKAPITVQIH
SPLELVHQYF TRLGVRYLIV VDERGLYRGV IFKKSYLKFL DDLEKQSGH
//
