ID A0A081FTM2_9GAMM Unreviewed; 290 AA.
AC A0A081FTM2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:KEA61877.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:KEA61877.1};
GN ORFNames=ADIMK_4024 {ECO:0000313|EMBL:KEA61877.1};
OS Marinobacterium lacunae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Marinobacterium.
OX NCBI_TaxID=1232683 {ECO:0000313|EMBL:KEA61877.1, ECO:0000313|Proteomes:UP000028252};
RN [1] {ECO:0000313|EMBL:KEA61877.1, ECO:0000313|Proteomes:UP000028252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK27 {ECO:0000313|EMBL:KEA61877.1,
RC ECO:0000313|Proteomes:UP000028252};
RA Singh A., Pinnaka A.K.;
RT "Marinobacterium kochiensis sp. nov., isolated from sediment sample
RT collected from Kochi backwaters in Kerala, India.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEA61877.1}.
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DR EMBL; JMQN01000059; KEA61877.1; -; Genomic_DNA.
DR RefSeq; WP_036191992.1; NZ_JMQN01000059.1.
DR AlphaFoldDB; A0A081FTM2; -.
DR STRING; 1232683.ADIMK_4024; -.
DR PATRIC; fig|1232683.4.peg.3959; -.
DR eggNOG; COG2084; Bacteria.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000028252; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KEA61877.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028252}.
FT DOMAIN 3..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 290 AA; 30861 MW; F5F1C3D769E6B362 CRC64;
MAKVAFIGLG TMGYPMAGHL AKAGHDVCVY NRTHAKAESW VSQYGHRCAQ TPSEAAEGAE
FVMTCVGNDN DLAQVTLGED GVLKSLKPNA ILIDHTTASA EIARTLSNAC EERGCEFLDA
PVSGGQAGAE NGVLSVMAGG GHNAYLRAEP VIAAYAKASK HLGAAGSGQL TKMVNQICIA
GLLQGLAEAT HFLKRSGLDG EEVFDVIQHG AAGSWQMVNR HKTMLNDEFD FGFAVDWMRK
DLSLVLDEAR RNGARLPVTA LVDQFYADVQ NLGGGRWDTS SLLKRLEPGE
//
