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Database: UniProt
Entry: A0A081MZS8_9GAMM
LinkDB: A0A081MZS8_9GAMM
Original site: A0A081MZS8_9GAMM 
ID   A0A081MZS8_9GAMM        Unreviewed;       515 AA.
AC   A0A081MZS8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   10-OCT-2018, entry version 18.
DE   RecName: Full=NAD(P) transhydrogenase subunit alpha {ECO:0000256|PIRNR:PIRNR000203};
DE            EC=1.6.1.2 {ECO:0000256|PIRNR:PIRNR000203};
GN   Name=pntA {ECO:0000313|EMBL:KEQ11701.1};
GN   ORFNames=GZ77_24640 {ECO:0000313|EMBL:KEQ11701.1};
OS   Endozoicomonas montiporae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Endozoicomonadaceae; Endozoicomonas.
OX   NCBI_TaxID=1027273 {ECO:0000313|EMBL:KEQ11701.1, ECO:0000313|Proteomes:UP000028006};
RN   [1] {ECO:0000313|EMBL:KEQ11701.1, ECO:0000313|Proteomes:UP000028006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 24815 {ECO:0000313|EMBL:KEQ11701.1,
RC   ECO:0000313|Proteomes:UP000028006};
RA   Neave M.J., Apprill A., Voolstra C.R.;
RT   "Whole Genome Sequences of Three Symbiotic Endozoicomonas Bacteria.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CATALYTIC ACTIVITY: NADPH + NAD(+) = NADP(+) + NADH.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KEQ11701.1}.
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DR   EMBL; JOKG01000006; KEQ11701.1; -; Genomic_DNA.
DR   RefSeq; WP_034879452.1; NZ_JOKG01000006.1.
DR   EnsemblBacteria; KEQ11701; KEQ11701; GZ77_24640.
DR   Proteomes; UP000028006; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR008142; AlaDH/PNT_CS1.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR026255; NADP_transhyd_a.
DR   InterPro; IPR024605; NADP_transhyd_a_C.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   Pfam; PF12769; PNTB_4TM; 1.
DR   PIRSF; PIRSF000203; NADP_transhydrogenase_alpha; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00561; pntA; 1.
DR   PROSITE; PS00836; ALADH_PNT_1; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028006};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000203};
KW   NADP {ECO:0000256|PIRNR:PIRNR000203};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000203};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000203,
KW   ECO:0000313|EMBL:KEQ11701.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028006};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    168    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    403    421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    427    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    458    475       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    481    503       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    137       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      146    314       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
SQ   SEQUENCE   515 AA;  54848 MW;  917E345FBA932C1A CRC64;
     MRIGIPEEIQ ENENRVAATP DTVKKLIKLG YDIVIEAGAG EKASFDDAAF TEAGADIAER
     SSVWASDIVM KVNAPTDDEI ALLKDGATLA SFIWPGQNEP LMNKLGQRTI NVLALDSVPR
     LSRSQSLDAL SSMANIGGYR AVVEASHHFG RFFNGQITAA GKIPPAKVLV IGAGVAGLAA
     LGAAGSMGAI VRAFDTRPEV KEQVESMGAE FLELDLLLSE EEEQDSSDGY AKEMSQAFID
     AEMALFMEQA KDVDIIITTA LIPGRPAPKL ITEDMVKAMK PGSVVVDLAA QTGGNCECTE
     KDRAVVKHGV TVIGFTDMPS RLPTQSSQLY GTNLVNMLKL MTPEKDGNLV IDFDDEVVRG
     LTVIKEGNIT WPPPPVKVSA APAAKPEPVA TPDVKEEKNS RPWLKPALLA AGAALFAWFA
     NSAPASFLEH FTVFVLSSIV GYYVIWNVTS ALHTPLMSVT NAISGIIVVG ALVQMGSDSP
     IVLALSGIAL VVAMINIVGG FAVTQRMLKM FIRDQ
//
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