ID A0A081NHM4_9GAMM Unreviewed; 748 AA.
AC A0A081NHM4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN Name=relA {ECO:0000313|EMBL:KEQ17947.1};
GN ORFNames=GZ78_10030 {ECO:0000313|EMBL:KEQ17947.1};
OS Endozoicomonas numazuensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Endozoicomonadaceae; Endozoicomonas.
OX NCBI_TaxID=1137799 {ECO:0000313|EMBL:KEQ17947.1, ECO:0000313|Proteomes:UP000028073};
RN [1] {ECO:0000313|EMBL:KEQ17947.1, ECO:0000313|Proteomes:UP000028073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25634 {ECO:0000313|EMBL:KEQ17947.1,
RC ECO:0000313|Proteomes:UP000028073};
RA Neave M.J., Apprill A., Voolstra C.R.;
RT "Whole Genome Sequences of Three Symbiotic Endozoicomonas Bacteria.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEQ17947.1}.
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DR EMBL; JOKH01000002; KEQ17947.1; -; Genomic_DNA.
DR RefSeq; WP_034834935.1; NZ_JOKH01000002.1.
DR AlphaFoldDB; A0A081NHM4; -.
DR STRING; 1137799.GZ78_10030; -.
DR eggNOG; COG0317; Bacteria.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000028073; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028073};
KW Transferase {ECO:0000313|EMBL:KEQ17947.1}.
FT DOMAIN 416..477
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 670..745
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 748 AA; 84988 MW; CBA6F0845574640D CRC64;
MVKVREDHPV RFDGSVDLEA WLTRMQESFG VTGTDRLRAA CELSRWAEEE ARQQADTVWP
TGPGCFRTGL EMVEILAELK LDTETLVAAA LYRAVRERKL SMKQVEEDFG KTVVRLIKDV
QGMAAISELL NPARALVLDQ SQDQLEKVRK MLVSIIDDVR VALLKLAERT CAIRALRDAD
KDKRRRVARE VFEIYAPLAH RLGIGYIKWE LEDLSFRYLN PQDYKRIARL LDEKRTDRQQ
YIDHVVDQLK DALGEAQIEA NVYGRAKHIY SIWRKMKRKG LDFRDLYDIR AFRVITREVR
DCYAALGVVH SLFNHIPQEF DDYIATPKEN GYRSLHTAVF GPEGKTLEVQ IRTEAMHEEA
ELGVCAHWKY KGTDVNTKSD SYEEKLNWLR NVMEWHEELG DLGGIAEEWR SDVEPDRIYV
FTKAGHVVDL AVGATPIDFA FRIHSEVGLK CRGAKVGGRI VPLNHSLKTG NQVEILTGPN
AQPSRDWLNP DLGYVTTNRA RAKITSWLKK QDRDSNIIDG SNQLNAELKR LALTGINFNE
LLPQTPFKEL DDMHAAIGAG DYRVTQAVAL AQRELEPEAE KAFEIRTRTP QEKVSDSTIT
IDGVGNLLTQ MAGCCHPVPG DPIIGYITVG RGVTIHRQDC NNALNLQEQE PERLIEVNWG
HSPEYMYPVE IIITAYDRSG LLRDITIVLA NERVNVLSVQ TRTSKEDNIA NMLLTVEVQS
LQQLSTVLAK VNQLPNVIEV ARHRKEGK
//
