ID A0A081XKR9_STRTO Unreviewed; 378 AA.
AC A0A081XKR9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:KES04142.1};
GN ORFNames=BU52_26340 {ECO:0000313|EMBL:KES04142.1};
OS Streptomyces toyocaensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=55952 {ECO:0000313|EMBL:KES04142.1, ECO:0000313|Proteomes:UP000028341};
RN [1] {ECO:0000313|EMBL:KES04142.1, ECO:0000313|Proteomes:UP000028341}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 15009 {ECO:0000313|EMBL:KES04142.1,
RC ECO:0000313|Proteomes:UP000028341};
RA Hong H.-J., Kwun M.J.;
RT "The genome announcement of Streptomyces toyocaensis NRRL15009.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KES04142.1}.
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DR EMBL; JFCB01000029; KES04142.1; -; Genomic_DNA.
DR RefSeq; WP_037938513.1; NZ_JFCB01000029.1.
DR AlphaFoldDB; A0A081XKR9; -.
DR STRING; 55952.BU52_26340; -.
DR eggNOG; COG1063; Bacteria.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000028341; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08282; PFDH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000028341};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 25..137
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 185..255
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 378 AA; 40491 MW; 4AACE07B9552B147 CRC64;
MKAVVYKGPF EVAVEEVDNP SIQHPNDVIV KVTSTAICGS DLHMYEGRTA AEPGITFGHE
NMGIIAEVGP GVTALKEGDR VVMPFNVACG FCTNCVEGFT GYCLTVNPGF PGGAYGYVAM
GPWKGGQAEY LRVPYADFNC LKLPEGKEHE NDFILLADIF PTGYHGCELA QVRPGESVTV
YGAGPVGLMA AYSALLRGAR KVFVVDRVAE RLQKAEEIGA VPINFAEGDP VEQIHAQTEG
MGTDKGVDAV GYQAAAGGGT DREEPATVLN SLVRTVRATG MLGVPGLYVP SDPGAPDEQS
KQGMLLVAVG KLFEKGLRMG TGQCNVKRYN RFLRDMIIDG RAKPSFVVSH ELPLDQAPSA
YDKFDKRIEG YTKVVLHP
//
