ID A0A081XNR9_STRTO Unreviewed; 714 AA.
AC A0A081XNR9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:KES05192.1};
GN ORFNames=BU52_21150 {ECO:0000313|EMBL:KES05192.1};
OS Streptomyces toyocaensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=55952 {ECO:0000313|EMBL:KES05192.1, ECO:0000313|Proteomes:UP000028341};
RN [1] {ECO:0000313|EMBL:KES05192.1, ECO:0000313|Proteomes:UP000028341}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 15009 {ECO:0000313|EMBL:KES05192.1,
RC ECO:0000313|Proteomes:UP000028341};
RA Hong H.-J., Kwun M.J.;
RT "The genome announcement of Streptomyces toyocaensis NRRL15009.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KES05192.1}.
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DR EMBL; JFCB01000019; KES05192.1; -; Genomic_DNA.
DR RefSeq; WP_037936479.1; NZ_JFCB01000019.1.
DR AlphaFoldDB; A0A081XNR9; -.
DR STRING; 55952.BU52_21150; -.
DR eggNOG; COG2409; Bacteria.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000028341; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028341};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 183..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..337
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 714 AA; 75295 MW; E6693B9C46B49A5D CRC64;
MTGERGIARL VCGRRSKWLV LVLWLVVLLV TAPLAQKLTD AQDNDAASWL PGSAESTQVL
EISEDFRPEQ IPAIVVYARD SGLTAADRER IAEDVDQLRR LSDHGIRGAE TRGPVFDRQT
GPRAAQVFVP ITMDEQGWER IGPAVDSIRD DVGESVDGLA VHITGPGGTS ADFAEGFEGI
DSTLLFSAMA VVVVMLLITY RSPTLLLVPL FSVIVALFAA QALVYLLAEH GGLTVNGQSA
GILLVLVFGA GTDYALLLVA RYREELRRHE DRHEAMALAL HRAGPAVLAS GATVVVSMLV
LLAAEMNSTR GLGPVAAIGV AVALLALLTL FPALLVIFGR WIFWPVIPHH GTPDPAERGK
WARMGRGIAR RPRTVWAVTA AVLAICSLGL IQLRAEGIGN ADAFTGKPDS ITGQEVSARY
FPAGSGDPLV VVSDQAQARQ VGRAVAGTEG VVPDSLALPP GTKPAFEGKV LFEATMTAPA
DSEAAKQTVE RVRDAVHAVP DADAQVGGGT AALLDMDRAT THDNMLIIPL VLAVVMLILC
ALLRALIAPL LLIATVILSF AAALGLSALA FRHVFDYAGE PTDFPLFVFV FLVALGIDYN
IFLTTRIREE AARQGTRPGV VTGLAATGAV ITSAGLVLAG TFAALATLPM VAFAEIGFAV
ALGVLIDTFV VRSVLVTALF LDVGPKVWWP HRLAREDGGG TVGVPEADVS RSGG
//
