ID   A0A081XYJ0_STRTO        Unreviewed;       424 AA.
AC   A0A081XYJ0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H5 {ECO:0000313|EMBL:KES08613.1};
GN   ORFNames=BU52_00780 {ECO:0000313|EMBL:KES08613.1};
OS   Streptomyces toyocaensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=55952 {ECO:0000313|EMBL:KES08613.1, ECO:0000313|Proteomes:UP000028341};
RN   [1] {ECO:0000313|EMBL:KES08613.1, ECO:0000313|Proteomes:UP000028341}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 15009 {ECO:0000313|EMBL:KES08613.1,
RC   ECO:0000313|Proteomes:UP000028341};
RA   Hong H.-J., Kwun M.J.;
RT   "The genome announcement of Streptomyces toyocaensis NRRL15009.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KES08613.1}.
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DR   EMBL; JFCB01000001; KES08613.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A081XYJ0; -.
DR   STRING; 55952.BU52_00780; -.
DR   eggNOG; COG2304; Bacteria.
DR   OrthoDB; 4318225at2; -.
DR   Proteomes; UP000028341; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028341};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..424
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039047432"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..229
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          319..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..341
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  44796 MW;  C109B6D8FA3F779C CRC64;
     MIRRKRPVAG VCVLLAALTA GLALPAGAAA DEPAGQDAPK VNLLLDVSGS MRAKDIDGQS
     RMAAAKQAFN EVLDATPEEV ELGIRTLGAD YAGDDRKEGC KDTAQLYPVG PLDRTEAKTA
     VATLVPTGWT PIGPALLKAA DDLEGGDGSK RIVLISDGED TCAPLDPCEV AREIAAKGIG
     LTVDTLGLVP NAKLSRQLSC IAEATGGTYT SVEHQDELTD RVNELVDRAA EPVVTPVATQ
     GADTCAKAPT LRSGLYTDRE EFGQQRWYRV ELLPGQELRA SVSVAADRAV RPDHGVLLRA
     VTLHGREIVR GEAAGTGRTD VLSTGLRHPK PERDDDDSGK PAAETVCLAV THSFSAESGV
     KTTPGLPLEL TVDVVDGPHG ADDVASFGLG RGWWLLGALI LTGFVAGLLW GWLSRWRFAV
     WRTH
//