ID A0A081XZK6_STRTO Unreviewed; 679 AA.
AC A0A081XZK6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:KES08979.1};
GN ORFNames=BU52_02705 {ECO:0000313|EMBL:KES08979.1};
OS Streptomyces toyocaensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=55952 {ECO:0000313|EMBL:KES08979.1, ECO:0000313|Proteomes:UP000028341};
RN [1] {ECO:0000313|EMBL:KES08979.1, ECO:0000313|Proteomes:UP000028341}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 15009 {ECO:0000313|EMBL:KES08979.1,
RC ECO:0000313|Proteomes:UP000028341};
RA Hong H.-J., Kwun M.J.;
RT "The genome announcement of Streptomyces toyocaensis NRRL15009.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KES08979.1}.
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DR EMBL; JFCB01000001; KES08979.1; -; Genomic_DNA.
DR RefSeq; WP_037927123.1; NZ_JFCB01000001.1.
DR AlphaFoldDB; A0A081XZK6; -.
DR STRING; 55952.BU52_02705; -.
DR eggNOG; COG1657; Bacteria.
DR OMA; CWARQTI; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000028341; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..326
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 337..653
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 75228 MW; 0E5DAEC204A8F31E CRC64;
MTATTDGSTG AALPPRVTAA SENDTDIPEA AGVPDIAARA MRRATDFLLS RQDDQGWWKG
DLETNVTMDA EDLLLRQFLG IRDDDTTRAA ALFIRGEQRE DGTWATFYGG PGELSTTIEA
YVALRLAGDP PDAPHMAKAS AWVRERGGIA ASRVFTRIWL ALFGWWKWED LPELPPELIW
FPSWLPLNIY DFGCWARQTI VPLTIVSAER PVRPAPFPLD ELHTDPRHPC PPLPLAPANT
WDGAFQRLDR ALHALRRAVP RRLRAAAMNT AARWIIERQE NDGCWGGIQP PAVYSVIALH
LLGYDLNHPV MRAGLESLDR FAVWREDGAR MIEACQSPVW DTCLATIALA DAGLPADHPQ
LVKAADWMLG EQIVRPGDWS VRRPHLPPGG WAFEFHNDNY PDIDDTAEVV LALRRVKHHD
PERLDNAIGR GVRWNLGMQS KNGAWGAFDV DNTSPFPNRL PFCDFGEVID PPSADVTAHV
VEMLAVEGLA HDPRTRRGIR WLLAEQEPDG SWFGRWGVNY LYGTGSVVPA LTAAGIPGSH
PAIRRAVAWL EKVQNDDGGW GEDLRSYERA ARWSGRGAST ASQTAWALMA LLAAGERGSR
AVERGVQWLA ATQREDGSWD EPYFTGTGFP WDFSINYHLY RQVFPLTALG RYVHGEPFTK
KPVTARAGAG QPLAEAKGS
//