ID A0A083ZUY7_9GAMM Unreviewed; 3351 AA.
AC A0A083ZUY7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Tyrocidine synthase 3 {ECO:0000313|EMBL:KEY56866.1};
GN Name=tycC {ECO:0000313|EMBL:KEY56866.1};
GN ORFNames=SRDD_42430 {ECO:0000313|EMBL:KEY56866.1};
OS Serratia sp. DD3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=1410619 {ECO:0000313|EMBL:KEY56866.1, ECO:0000313|Proteomes:UP000017810};
RN [1] {ECO:0000313|EMBL:KEY56866.1, ECO:0000313|Proteomes:UP000017810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD3 {ECO:0000313|EMBL:KEY56866.1,
RC ECO:0000313|Proteomes:UP000017810};
RX PubMed=25212623;
RA Poehlein A., Freese H.M., Daniel R., Simeonova D.D.;
RT "Draft Genome Sequence of Serratia sp. Strain DD3, Isolated from the Guts
RT of Daphnia magna.";
RL Genome Announc. 2:e00903-14(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEY56866.1}.
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DR EMBL; AYKS02000114; KEY56866.1; -; Genomic_DNA.
DR RefSeq; WP_037387142.1; NZ_AYKS02000114.1.
DR STRING; 1410619.SRDD_42430; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 9757559at2; -.
DR Proteomes; UP000017810; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000017810}.
FT DOMAIN 949..1023
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1997..2072
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3049..3124
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3351 AA; 376834 MW; A7D3F674BD3C8625 CRC64;
MELIAISPYT KMFWNEYILN PKSFEYNMVS IQTIDGDFDI NRLRHAIQGV VRDYILFHHV
LSEKDGQLHW VKTEKSITLE LLDSSCDLAS LICTPFDLTE GPLCRFYLIE MGAQRYDFIV
VLHHVLIDGL SGQEFYDVLS YYYNQGQQAL PNTPNLAQMQ QLYKQYDHDV SSLKQDFNSL
AFWRELLADC PPRVDLPYIR TESSGSDSSG GVRFSLSLSE WHRLKDGVKY ANPFLIFKTL
WALLIACQSE QKTVHIGYPV AAEGGKELYY GAQVNTAIFP LRLLPQATFA SLYRDTLDYT
KKLKASGKLR HTKLPTYDIL SQSQIQQLNV NFTQAYLKDS PLVFNGCQIS VDHRFNVDLA
GSELLLEYQQ SENAFNFRLR YKSDLFDETQ MLELAEQYLN LLRSVLNEPE RLISTFSYLT
PQQEQRLQDH YHSAAPQSPT QTTLLSGFEK HSHLYPERMA LKDEKEALSY RELEQRSTRL
AQHIRAEYLR ICGQEMPADT LIPLYLQRSV DAVVGILAIM KAGAAYVPLD PHAPAQRLAY
ILQDVNSPLV LTQAKLQDTI LQNAPDSHCL LIDQQEHTAL IDNIPLPELD SRQLAYVIYT
SGTTGRPKGT LCEHRGAVNM IQGHTQRLLA NQHHVLNCMQ FATFAFDAHV FEVFIALDNG
HCLCIANEAQ RLDLPLLTKQ MAEWQINFCF LPPALLSTKP TFPDSVRYLG VGGEATSQDV
LDHYLACGLQ VANMYGPTEA SVSASVNLYR NNGARNIGHM ITNMRGYVVD ENFHLLPLGV
EGELYLAGAG LARGYLGQPE LTASLFIDNP FHQEMDYRRL YRTGDRVRRL PDGSLEYCGR
KDQQVKINGY RIELGEIESV MRNLPGIAEA VVIARKQPSP QLLAWFVLAP GSNLTPEEVN
QQLAEQLPHY MVPGAMMAIP AIPLTVSRKV DYRALPEPAL IEQNTPFRTP STPLESQLLV
LFNRLLNSNA GIDDHFYRLG GNSILAIKLC HEINKQLGVN VSALTLHQYP TVATLSSYIA
QQEPTVQEET ILATGCQTAP LSFQQSRLWF MQQLSTEATH YLSPVLLQLS ADVDCAAFIK
SLQAIVTRHQ VLRSLIKQDK AGEACQVVTD QVLAVPVHVV TAEGYATCLQ QALQQPIDLT
RELPLRAAIY QYQDATGNAN TASLLVFHHI VFDGWSMDVL MKELAIFYHH FMQPTAPPPA
ALPLQYLDYA FWQHQQREVE IKAEDLAFWH RTLADCQQLD IPPDYVRPAA FDTRGDNCDV
MLPADLLASL NQLAREERVS LHGVMLSAFT LLLTRYTGQD DVMVGTPLAN RSQPELEDLI
GFFVNTLPLR NRVNNEISVS AFIHQVATNT LQVQQHQSLS LEQLVDSLAL PRDFSRHPLF
QVMFALEDYV NNADYPSWLS VEDLSRYEQT AKFDLTLTLT PTENQMSARF NFATALFKKS
SIRQLAGYFV SILQQMVQYR DEPLKTLSLF PAEKIPQWLS THREQRFGYS FERTLHHDFM
RNAQQYPQAV AVIDTFGEMT YSALYQAAST LATQLRLQGE IQGDAIAILA DKGRQQPVAM
LAALMCGKAF LPMDKGWPLQ RRLGVMAQAG INTLLSNEAW VTPDINVVVL NSAGHAPTLP
QPEWLLPPID ATPDNLAYII FTSGSTGTPK GVAIEHRSVV NMIEGTNRYF AIDQNDRSIA
LSALSFDLAI HDIFSVLSAG GAVVMPAESD RTNPEAWYQL MIAHRVTTWL SAPALLELLL
DYVNSIGGVS GPEPALRAVM VGGDWIVTSL PERCRQWAPH SRFCSVGGAT EAAVFSILYE
VPHQPVLSVS IPYGKPLPHQ RFYILDAWLR PVPEGVKGEI YIAGVGLARG YYGDNQRTAD
SFFWHELLQE RVYRTGDAGR FLHDGNIEFM GRIDQQVKIN GYRIELGEIE NIALSYPILT
ACCVMLIPHP QPYLAAYIVA NEPVDIPALS QYLRSQLPQY MMPKAFVQIE SMPLTENGKI
ARKALPVPQY EQRDFVVADS DWERECCEIW CELLKRQRVS VEDNFFSLGG NSILAIQACY
QISHRLQRDV TLSDLGQHPT IRNLCNYLKK PGDDETQPLV IPALQLDTYP LSSSQMQLWF
IENLNGGSHL YHVPMLFRLN EDLDPIAYCQ SLRAIVARHH VLRSVICQQQ ALTALSRLVD
SELEIARLVL DADTWQQQLL QDIDQPFRLE AEIPIRARIY QVKQPDNTHQ HYCLIVVHHL
AFDGWSQTIF LQEWAALYQA YRTGLHPALP EPSLQYGDYA SWQQTYLSSA NADRLKAFWQ
QHLQGWQMLE MPLDYVRPAQ FDHRGANHCV TLPDDLVAQT ERFVQREGVT PFALFLSAFN
LLLNAFSGQQ DILVGTPVAN RPTAETRAVI GFFVNTLPLR TQIDDNMALS DYVHEVFNTS
LEAQKYQSLP LEQLIDHLQV PRDLSRHPLF QVLFVLEDAT QNTALPAWLV PQSLVEQYQA
AKFDLMLSIQ KDVGCTQAVF NYATALFTPE TLTCLSQYYL TILEQIVEQG SWRINQLTLV
PPAEVTSMRA SWQTSPPAYD FERAIHHDFI QQARLQPQAV AIIDSLGELS YGELYQEALT
LSLQLRQYTD GQSETIAVMV DKGRAQIIAV LAIVMAGKAY LPLDGSWPER RRLEVIAQSQ
TPVILSSQPW QNIEQARLLL IDPHGIVAEL PPPQPGEPVL PAPHDLAYVI FTSGSTGIPK
GVAVEHRGAV NSIVDTIQQL GLDKQDRGLA LSALSFDISA FDIFGILSVG GTMVMPSEVE
RYQPDAWHRL MVNHGVTFWN SAPSVITLLV EYLESRETAG EGWPMLRTVV LVGEVIAKQL
PARIRQWREG CRVVSTGGAT ESSIWSILYD IPDAPILTPS VPYGKAMAHQ RFYVLDSHLR
VLPPCLPGEQ YIGGAGVARG YFRNEAVTQE RFIYHPELGE RLYRTGDAGR YLPDGNLEFM
GRMDFQVKIN GYRVELGEVE SSALAFGTIK SCCAIVWKDQ QQERLALYYV CDEPLIEAEL
LEFLSQRLPL YMIPTALIQL QALPYNSSGK LDRKALPAPQ IVEQNVYVAP SNPLEQQLCA
LWQKTLKREQ IGMTDDFFRS GGTSLMAISV CMKLSELLKT AVPVVRLFQC RTLKNLLATC
ENHLVLPLTQ ITQGLPALWM IHPALVGAEA FYPFAQTLQG KMNGYGVDNY NLYHRPTISS
LATLADRYLE EMITHGLLAG PVQILGWSLG GLIALEIAAQ LEARGIQEIS LYLLDSFYQQ
TTEKTSLDTL LATLGLTGET AERAQAVAEV EDRLSQAKLS HKLQTTQVTL FKAMRANPDL
PDDVMKPLIA VPDNGLKTVC EHLRVIPLAC HHHDILEYGD EIIKVICPQK R
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