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Database: UniProt
Entry: A0A084A2F8_9GAMM
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ID   A0A084A2F8_9GAMM        Unreviewed;       464 AA.
AC   A0A084A2F8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   20-JUN-2018, entry version 34.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA_1 {ECO:0000313|EMBL:KEY59487.1};
GN   Synonyms=dnaA {ECO:0000256|HAMAP-Rule:MF_00377}, dnaA_2
GN   {ECO:0000313|EMBL:KEY58291.1}, dnaA_3 {ECO:0000313|EMBL:KEY56776.1},
GN   dnaA_4 {ECO:0000313|EMBL:KEY56556.1};
GN   ORFNames=SRDD_17700 {ECO:0000313|EMBL:KEY59487.1}, SRDD_25370
GN   {ECO:0000313|EMBL:KEY58291.1}, SRDD_43650
GN   {ECO:0000313|EMBL:KEY56776.1}, SRDD_46010
GN   {ECO:0000313|EMBL:KEY56556.1};
OS   Serratia sp. DD3.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=1410619 {ECO:0000313|EMBL:KEY59487.1, ECO:0000313|Proteomes:UP000017810};
RN   [1] {ECO:0000313|EMBL:KEY59487.1, ECO:0000313|Proteomes:UP000017810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DD3 {ECO:0000313|EMBL:KEY59487.1,
RC   ECO:0000313|Proteomes:UP000017810};
RX   PubMed=25212623;
RA   Poehlein A., Freese H.M., Daniel R., Simeonova D.D.;
RT   "Draft Genome Sequence of Serratia sp. Strain DD3, Isolated from the
RT   Guts of Daphnia magna.";
RL   Genome Announc. 2:e00903-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KEY59487.1}.
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DR   EMBL; AYKS02000123; KEY56556.1; -; Genomic_DNA.
DR   EMBL; AYKS02000118; KEY56776.1; -; Genomic_DNA.
DR   EMBL; AYKS02000071; KEY58291.1; -; Genomic_DNA.
DR   EMBL; AYKS02000047; KEY59487.1; -; Genomic_DNA.
DR   RefSeq; WP_023489198.1; NZ_AYKS02000123.1.
DR   EnsemblBacteria; KEY56556; KEY56556; SRDD_46010.
DR   EnsemblBacteria; KEY56776; KEY56776; SRDD_43650.
DR   EnsemblBacteria; KEY58291; KEY58291; SRDD_25370.
DR   EnsemblBacteria; KEY59487; KEY59487; SRDD_17700.
DR   Proteomes; UP000017810; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017810};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017810}.
FT   DOMAIN      161    363       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      372    441       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     169    176       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      323    343       {ECO:0000256|SAM:Coils}.
FT   COILED      441    461       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   464 AA;  52306 MW;  3071754A99E63EC4 CRC64;
     MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN
     GLLNDFCGTD VPLLRFEVGS KPLTRTISQA ATASVNNAPA APVARTAAPS RHSWDNAAPP
     PELSYRSNVN PKHTFDNFVE GKSNQLARAA ARQVADNPGG AYNPLFLYGG TGLGKTHLLH
     AVGNGIMARK ANAKVVYMHS ERFVQDMVKA LQNNAIEEFK RYYRSVDALL IDDIQFFANK
     ERSQEEFFHT FNALLEGNQQ IILTSDRYPK EINGVEDRLK SRFGWGLTVA IEPPELETRV
     AILMKKADEN NIRLPGEVAF FIAKRLRSNV RELEGALNRV IANANFTGRA ITIDFVREAL
     RDLLALQEKL VTIDNIQKTV AEYYKIKVAD LLSKRRSRSV ARPRQMAMAL SKELTNHSLP
     EIGDAFGGRD HTTVLHACRK IEQLREESHD IKEDFSNLIR TLSS
//
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