ID   A0A084QHL6_STAC4        Unreviewed;       887 AA.
AC   A0A084QHL6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
GN   ORFNames=S40285_00320 {ECO:0000313|EMBL:KFA63451.1};
OS   Stachybotrys chlorohalonata (strain IBT 40285).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Stachybotryaceae; Stachybotrys.
OX   NCBI_TaxID=1283841 {ECO:0000313|EMBL:KFA63451.1, ECO:0000313|Proteomes:UP000028524};
RN   [1] {ECO:0000313|EMBL:KFA63451.1, ECO:0000313|Proteomes:UP000028524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 40285 {ECO:0000313|EMBL:KFA63451.1,
RC   ECO:0000313|Proteomes:UP000028524};
RX   PubMed=25015739; DOI=10.1186/1471-2164-15-590;
RA   Semeiks J., Borek D., Otwinowski Z., Grishin N.V.;
RT   "Comparative genome sequencing reveals chemotype-specific gene clusters in
RT   the toxigenic black mold Stachybotrys.";
RL   BMC Genomics 15:590-590(2014).
CC   -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC       {ECO:0000256|RuleBase:RU369098}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
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DR   EMBL; KL660737; KFA63451.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A084QHL6; -.
DR   STRING; 1283841.A0A084QHL6; -.
DR   HOGENOM; CLU_013363_0_0_1; -.
DR   InParanoid; A0A084QHL6; -.
DR   OMA; GMMASPR; -.
DR   OrthoDB; 1356823at2759; -.
DR   Proteomes; UP000028524; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Nonsense-mediated mRNA decay {ECO:0000256|RuleBase:RU369098};
KW   Nucleus {ECO:0000256|RuleBase:RU369098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028524}.
FT   DOMAIN          75..190
FT                   /note="Telomerase activating protein Est1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10374"
FT   DOMAIN          200..475
FT                   /note="DNA/RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10373"
FT   REGION          475..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          782..859
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..828
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        845..859
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   887 AA;  97961 MW;  D6D05E1611FC1DF1 CRC64;
     MATSTSQAAP AAQSWHQAQK LRKHLTKQLE KLRADSGPKL DLAQLDAMDG VLEKLRLACV
     QTIFLDFEYA FAQEAERHLW QCHTSINSEY RSILGRLKNS PNAVEKRKIE KTYNNFLRIA
     QKFYRGYIQR LAARYDIPEL KRVAQGIEVE TIPNADTISP ESQDLRRHVL HSCHSTLVRL
     GDLARYRIQA RHKKSGYDTA LTYYSLAHDL MPASGFAIHQ MGIVNVDEGN HLDAVYHLYR
     AWVAANPHPM AINNLECEFK VLRVQSSARN LGQSTPRDVL SMWFVKLHAN FYKGEVFQAH
     KELEGEVIHR LEMVARQPDA TKTLLKMVLI NISAYHVASL KLAKNPDSQA SLFGQYSLAL
     NARFIFTLCN VMSTELVEAT SKEDLDGTAK AGSMQIVDAL LPLLRTYCMW LATCRHALFG
     AADSAGTQAS TMMQSLAQTF TLLCDETYKH ENPASCPYLL AEDLEFRGAR PLDEEQVPQP
     CRSYSQVDGS IKPYPPAPEQ RLTPPRESLA RILDVLRCAY FLAEDDSVPL VHRVQGGRLV
     FQYQQKHLNM VARSEAAPTN GPSMNAVEPA ATRQQRVPVA VQESPEPADI PSLQGPIAVP
     DVEPRQLTEV EEAAEHTVFQ MLAPFLRPPT SEPPRILSPA HISHGAQNVA LRANSSSFSA
     EPSPTGSVEP GKFEPLPWNW VYTPTPHTAQ EQTMAEGQEA FLTHASPGLQ SAGINNARHS
     VDDPFVSPTR ASYDAQAPQD VGLASRSPSS AVEEAHRNDL LQSFVNAGPS SRRSIFSTYG
     TAANASRKES EPSTFAHWRT PGLDNPLSSA SEFSHPSSLY QGTPANGAGN RRGTAYELPA
     NQAQLPGLHQ GNSRSSQIDR VTLNYDAAVF DAAHYTGTRG PNSGPGR
//