ID A0A084QIX2_STAC4 Unreviewed; 748 AA.
AC A0A084QIX2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000256|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000256|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000256|HAMAP-Rule:MF_03027};
GN ORFNames=S40285_03786 {ECO:0000313|EMBL:KFA63907.1};
OS Stachybotrys chlorohalonata (strain IBT 40285).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Stachybotryaceae; Stachybotrys.
OX NCBI_TaxID=1283841 {ECO:0000313|EMBL:KFA63907.1, ECO:0000313|Proteomes:UP000028524};
RN [1] {ECO:0000313|EMBL:KFA63907.1, ECO:0000313|Proteomes:UP000028524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 40285 {ECO:0000313|EMBL:KFA63907.1,
RC ECO:0000313|Proteomes:UP000028524};
RX PubMed=25015739; DOI=10.1186/1471-2164-15-590;
RA Semeiks J., Borek D., Otwinowski Z., Grishin N.V.;
RT "Comparative genome sequencing reveals chemotype-specific gene clusters in
RT the toxigenic black mold Stachybotrys.";
RL BMC Genomics 15:590-590(2014).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. Within the NOP7 complex ERB1 appears to interact directly with
CC NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000256|HAMAP-Rule:MF_03027}.
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DR EMBL; KL660712; KFA63907.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084QIX2; -.
DR STRING; 1283841.A0A084QIX2; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; A0A084QIX2; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 5472008at2759; -.
DR Proteomes; UP000028524; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03027};
KW Reference proteome {ECO:0000313|Proteomes:UP000028524};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03027};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03027}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 132..392
FT /note="BOP1 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01035"
FT REPEAT 399..433
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 83841 MW; 8865A1A16F2D401F CRC64;
MPRASMASRP QPRKRRISPE ATSSADELDG LALDGVLSQS DDDSEDERSD SAHTRDTPPG
VANSLGPATK SNGFGLSNKL SGSQEVANYT VVSDANGNER FEYDEVDPVY DSDDSDAQEA
TNTIGNIPLS FYDSYPHIGY DINGKKIMRP ATGEALDSLL NSIELPKGWT GLTDPQTGLP
LNLSQSELEL LRRIQMNEIT EEGYDPYPEL VPYFTSIEEQ MPLSAAPEPK RRFVPSKHEA
KRVAKLVRAI REGRILPYKP PADREAEEET DVAYDIWVNE EPQDRHIMNI PAPKLAPPGY
DLSYNPPPEY LPSADEKRAW ESTDPEDREK DYLPARFDSL RKVPGYGEFV KERFERCLDL
YLAPRIRKNR LNIDPDSLLP KLPSPQSLKP FPTLCQTIFR GHEGRVRTVS FSPDGEWVAS
GGDDGTVRVW ALNGHQEWQA KIHYEEPVNV VRWRPAKDGF ILAAAAGEDL FFIVPPLVSD
AVARASRELL DAGFGHAANR SQVTAVDGVK KDSPAKWQRP GSKLEDMGVL LKATVRTTIK
AINWHRRGDF LCTVSPTGQR SSVAIHTLSK HLSQIPFRRL PGLAQTALFH PLRPLFFVAT
QRTIRCYDLQ RQELIKVVQP GARWISSFDI HPGGDNLIVG SYDRRLLWHD LDLSTRPYKT
MRFHAEAIRA VKYHRSLPLF ADASDDGTLQ IFHGKVVNDL MESATIVPVK MLKGHKVVNK
LGIMDMDWHP RHPWCLSAGA DGTCRLWA
//
