ID   A0A084QR69_STAC4        Unreviewed;       836 AA.
AC   A0A084QR69;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=DNA repair metallo-beta-lactamase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=S40285_00727 {ECO:0000313|EMBL:KFA66454.1};
OS   Stachybotrys chlorohalonata (strain IBT 40285).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Stachybotryaceae; Stachybotrys.
OX   NCBI_TaxID=1283841 {ECO:0000313|EMBL:KFA66454.1, ECO:0000313|Proteomes:UP000028524};
RN   [1] {ECO:0000313|EMBL:KFA66454.1, ECO:0000313|Proteomes:UP000028524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 40285 {ECO:0000313|EMBL:KFA66454.1,
RC   ECO:0000313|Proteomes:UP000028524};
RX   PubMed=25015739; DOI=10.1186/1471-2164-15-590;
RA   Semeiks J., Borek D., Otwinowski Z., Grishin N.V.;
RT   "Comparative genome sequencing reveals chemotype-specific gene clusters in
RT   the toxigenic black mold Stachybotrys.";
RL   BMC Genomics 15:590-590(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC       family. {ECO:0000256|ARBA:ARBA00010304}.
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DR   EMBL; KL660440; KFA66454.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A084QR69; -.
DR   STRING; 1283841.A0A084QR69; -.
DR   HOGENOM; CLU_005260_4_0_1; -.
DR   InParanoid; A0A084QR69; -.
DR   OMA; AQVHMHS; -.
DR   OrthoDB; 23465at2759; -.
DR   Proteomes; UP000028524; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.12650; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR011084; DRMBL.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR   PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR   Pfam; PF07522; DRMBL; 1.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028524}.
FT   DOMAIN          391..510
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF12706"
FT   DOMAIN          648..781
FT                   /note="DNA repair metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF07522"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  92917 MW;  D9B1B38E0F6A5CDA CRC64;
     MGTSAKSSRS HTPRKPAAKA QKPVAANASI LAFFKKAEKR ETSLFIGDTN EVAGPNEDLY
     GDDPRYNEIE SPIKKRRLSE DAADTSIRAK PAAPVVEKAP EVEAEPEVVV VPKKPKPRGF
     MPFAMDSESD NDDDDDDNKE IIAKTIAATN PKRSSPSPPK DVEISLKLET TRNPFIKDEP
     VMLKHEDSTY EQFDHIEEQI DDQGDLDMDD FEGEEFREMR YMREQAQLEA QDAGGGSFED
     FPDGGFEETL RMDSCCPICE ASLTRISVED ANRHVNACLD GNPIPLPQEI DAPEKTPKVE
     ITEIGKRFLR AAVPRPAQPN PLEEKGSDNA PRSAFSKLMS NNAEDSAWAA ASAQEHASRG
     RPAYERTCPF YKIMPGFSIC VDAFRYGAVQ GCKAYFLSHF HSDHYIGLTA SWCHGPIYCS
     KVTGSLVKKQ LRTAAQWVVE LEFDKTCEIP GTGGASVTMI PANHCPGSSL FLFEKQETLG
     SNTRTKRILH CGDFRACPAH VEHPLLRADV KDSISGKMKQ QKIDICYLDT TYLNPRYSFP
     PQADVITACA DLCASMSADP ECQDDVWEKQ ELAAGTPAVS KYFHSTKSSD ADAASPQKSK
     PRQRLLVICG TYSIGKERIC VAIAKALGSK IFASASKIRI CKQLDDPELT ALLTSDPLEA
     QVHMQMLMEI RAETLQEYLN SYKPHFSRIV GLRPSGWNFR PANGKAITAN TAPSTIPTQQ
     VLHGKGWRTR FGYRDFVRQR GSTKEAMCIG VPYSEHSSFR ELAMFVMSLR IEKVIPTVNV
     GSEQSRKRMK GWIDRWMAER RKGGLLRPLI EGQDVEDDGK HELWDGKSGK GGSAWW
//