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Database: UniProt
Entry: A0A084UBB8_9RHIZ
LinkDB: A0A084UBB8_9RHIZ
Original site: A0A084UBB8_9RHIZ 
ID   A0A084UBB8_9RHIZ        Unreviewed;       436 AA.
AC   A0A084UBB8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   10-APR-2019, entry version 18.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=EL18_01284 {ECO:0000313|EMBL:KFB10254.1};
OS   Nitratireductor basaltis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Nitratireductor.
OX   NCBI_TaxID=472175 {ECO:0000313|EMBL:KFB10254.1, ECO:0000313|Proteomes:UP000053675};
RN   [1] {ECO:0000313|EMBL:KFB10254.1, ECO:0000313|Proteomes:UP000053675}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMTGB225 {ECO:0000313|EMBL:KFB10254.1,
RC   ECO:0000313|Proteomes:UP000053675};
RA   Gan H.Y.;
RT   "Draft Genome Sequence of Nitratireductor basaltis Strain UMTGB225, A
RT   Marine Bacterium Isolated from Green Barrel Tunicate.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFB10254.1}.
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DR   EMBL; JMQM01000001; KFB10254.1; -; Genomic_DNA.
DR   RefSeq; WP_036480902.1; NZ_JMQM01000001.1.
DR   STRING; 472175.EL18_01284; -.
DR   EnsemblBacteria; KFB10254; KFB10254; EL18_01284.
DR   PATRIC; fig|472175.3.peg.1297; -.
DR   OrthoDB; 1464088at2; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000053675; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053675};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:KFB10254.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053675};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      355    436       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      10     17       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    207    207       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     107    107       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     192    192       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   436 AA;  46399 MW;  32A01E19497D438F CRC64;
     MADALRIGIA GLGTVGASVI RMLDAKAQEL TRQCGREIVV TGVSARDRNR DRGVDVSNAR
     WFDDSVELAR SQDIEVFVEL IGGEDGPARA SVKAALEAGK HVVTANKALL SRHGVSLAAA
     AEKKGVLLNY EAAVAGGIPI IKTMREALAG NQVSRVFGIM NGTCNYILTR MEAEGISFED
     CLKDAQRLGY AEADPTFDIE GHDTAHKLSI LTSLAFGCRI SADDIYMEGI SNITQADIRA
     ASDLGFRIKL LGVAVKTDSG IEQRVHPTMV PTSSVIAQVH GVTNAVAVET DYLGELLLTG
     PGAGGDATAS AVTGDIADIA KSRPGFQHGP VFGWPARELT PYKRARMRSH AGGYFIRLTV
     HDRTGVFAAI AKRMADSEIS LESIVQHGDA TADQHKTVIL VTHETTEAAV RKAVDGITRD
     GHLVDKAQVI RIERAA
//
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