ID A0A084VBW6_ANOSI Unreviewed; 584 AA.
AC A0A084VBW6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Rab proteins geranylgeranyltransferase component A {ECO:0000256|PIRNR:PIRNR016550};
GN ORFNames=ZHAS_00002175 {ECO:0000313|EMBL:KFB35460.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB35460.1};
RN [1] {ECO:0000313|EMBL:KFB35460.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC002175-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Substrate-binding subunit (component A) of the Rab
CC geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab
CC proteins and presents the substrate peptide to the catalytic component
CC B. The component A is thought to be regenerated by transferring its
CC prenylated Rab back to the donor membrane.
CC {ECO:0000256|PIRNR:PIRNR016550}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR016550}.
CC -!- SIMILARITY: Belongs to the Rab GDI family.
CC {ECO:0000256|ARBA:ARBA00005593, ECO:0000256|PIRNR:PIRNR016550}.
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DR EMBL; ATLV01009632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524540; KFB35460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VBW6; -.
DR STRING; 74873.A0A084VBW6; -.
DR EnsemblMetazoa; ASIC002175-RA; ASIC002175-PA; ASIC002175.
DR VEuPathDB; VectorBase:ASIC002175; -.
DR VEuPathDB; VectorBase:ASIS022032; -.
DR OMA; LMKFLTA; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR Gene3D; 3.30.519.10; Guanine Nucleotide Dissociation Inhibitor, domain 2; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018203; GDP_dissociation_inhibitor.
DR InterPro; IPR001738; Rab_escort.
DR PANTHER; PTHR11787; RAB GDP-DISSOCIATION INHIBITOR; 1.
DR PANTHER; PTHR11787:SF4; RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A; 1.
DR Pfam; PF00996; GDI; 2.
DR PIRSF; PIRSF016550; Rab_ger_ger_transf_A_euk; 2.
DR PRINTS; PR00891; RABGDIREP.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR016550};
KW GTPase activation {ECO:0000256|PIRNR:PIRNR016550};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT REGION 527..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 64510 MW; 6CC4ADDA59FC68A1 CRC64;
MEEELPTEFD LIVIGTGLTE SIVAAAASRI GKTVLHLDTN DYYGGYWASF NLDAFRKYLN
NQQPASAPCT IENNFLRLCP NPTAVQNGCE KWNTLVEVGD VDGWSREKIE QEFRRFNIDL
TPKLLYARGS MVELLISSNI CRYAEFRALD RVATLWEGKI MTVPCSRSDV FTSKDVNVIE
KRLLMKFLQS CASYEEGQDV AENKPEELDG KTFLEHLQSH KLTPNLIHYV LYTIAMGNDR
TPAREGLAGV KKFLMSLGHY GNSPFLFPVY GCGEIPQCFC RLCAVFGGIY CLNKAVEGTN
RFESVKCGKQ NIRSKDLVVG QGYLSQDVFA KGSTTETAKE NPCGRLARAV ILTNVPFGGA
SQNPGGGGVA IMKLPPVSGH REGATILQMS HYSGTCPKEI YLIHVTTLAL SANPEDDLKP
YIAQIFSYDY CNTAPATASG EENAEPAEPQ SDNTTSTILY EAYFNIPSCV ACTVASNSVV
PAGIRLTCGP YHELDYDQSI EQARHIFRDM YPDEEFLPRA PDPEEIIIGE EEPVQEPRGD
ATDANDDEPV DNASECRDTE SDSALAQEAK EEAIDKAEEC TEQK
//
