ID A0A084VI95_ANOSI Unreviewed; 245 AA.
AC A0A084VI95;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Enhancer of split mgamma protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ZHAS_00004938 {ECO:0000313|EMBL:KFB37689.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB37689.1};
RN [1] {ECO:0000313|EMBL:KFB37689.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC004938-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ATLV01013336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524853; KFB37689.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VI95; -.
DR STRING; 74873.A0A084VI95; -.
DR EnsemblMetazoa; ASIC004938-RA; ASIC004938-PA; ASIC004938.
DR VEuPathDB; VectorBase:ASIC004938; -.
DR VEuPathDB; VectorBase:ASIS024459; -.
DR OMA; NSTGPMW; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19741; bHLH-O_ESMB_like; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF12; ENHANCER OF SPLIT M3 PROTEIN-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 29..86
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 103..136
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 150..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 26969 MW; C3030FA32D6B1EAA CRC64;
MDYANMVSES SLNGKLQSSL EPVSRTYQYR KVMKPMLERK RRARINRCLD ELKELMVSAL
QSEGENVAKL EKADILELTV RHLHKLRRQQ RLAANPVIDA DRFRAGFTHA ANEVSRCLAS
TPGVDIKLGT KLMTHLGHRL NDLDKVSPLS VHVESPGSPS GAPNSASPPI SPFSGASSSA
GDVPMYPMPL TPQSYRSEES SSLLLAPSTT PSPNPSECDG EHHHHQTTGL LKIQQSGCEA
VWRPW
//
