ID A0A084VIW0_ANOSI Unreviewed; 837 AA.
AC A0A084VIW0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE RecName: Full=Vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|ARBA:ARBA00017947, ECO:0000256|PIRNR:PIRNR007949};
GN ORFNames=ZHAS_00005225 {ECO:0000313|EMBL:KFB37904.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB37904.1};
RN [1] {ECO:0000313|EMBL:KFB37904.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC005225-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Note=Cytoplasmic, peripheral membrane
CC protein associated with late endosomes/lysosomes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR EMBL; ATLV01013411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524855; KFB37904.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VIW0; -.
DR STRING; 74873.A0A084VIW0; -.
DR EnsemblMetazoa; ASIC005225-RA; ASIC005225-PA; ASIC005225.
DR VEuPathDB; VectorBase:ASIC005225; -.
DR VEuPathDB; VectorBase:ASIS016457; -.
DR OMA; HMTIRDH; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|PIRNR:PIRNR007949};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007949};
KW Membrane {ECO:0000256|PIRNR:PIRNR007949};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 6..424
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 519..830
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 837 AA; 93823 MW; FC93C3D501C30641 CRC64;
MSLLCNTGDW FTLGQGNAFR KIELYTMDWP ASINLDNMTI HAAPYGGPIA VVKDPKSFIK
LDGGSSARPV IRVFNCVGKL MSSINWDCGN LVALGWSDCE ELVGVQDDGT IFIHDMFGNF
VHKFSVGKDV ADVVAAKIFA SASGTGVAVM TSGYKIYILN NIKDPKSRPL SDLLNITSAL
SAWEMVCKDR TTSCLLAMGN EITVVRLGDN AFASHAVAMK SEFKSIALMS VSFDHQHVAM
LTNTGCVWMG SSDLKQKYGE FATGRQDKPI HLAWCIDGTT QVESQAVIVA YMTLILIIGT
TGESSVYTYD SPMTLIPEMD CVRVLTSSCH ELIQKVPLST SKIFGINISE PASFLFEAHR
KFQERSHQSD EYLCLIQGKL SAAVADCVEA AGHEFDPNTQ KSLIRAAYFG KSFITDYNCT
EYIRMCKTLK VLNVLRDRNV AIPITIQQFN HLQPVVILDR LVFRKHYSLS IHTAKYLRLQ
ETRILEHWAF QKIALDKNED EVARKIEAKF SSADLLEPMS FANVAEKAQQ LGKTKLAITL
LEREKKKKLQ VPLLLKLGAS EKALKAATES GDIDLIYMAL LEMKNTTALA KFHMTIRNYS
LAQSLYKKYC QLNSLSTLKD IHSQEDDFLA QAELGLREAL ALGNLDASIP DIGGNYRRAG
KAAEAELADE TKRLLKHQKT LQDKYHRDFF GLPLHALVRQ LLQLGDLRYA EKLKGEFRMP
ERRFCWLRVR TLAENYQWEE LERFARAKKS AIGYEPFVEV CLQQRNVAEA KKYLPRCAEE
NKLKWYLRAG CYADAANIAF VQKDIDSLLK IHDHCTNADP ALLATVENMI GQLSSKK
//
