ID A0A084VMC0_ANOSI Unreviewed; 639 AA.
AC A0A084VMC0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=ZHAS_00006442 {ECO:0000313|EMBL:KFB39114.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EnsemblMetazoa:ASIC006442-PA, ECO:0000313|Proteomes:UP000030765};
RN [1] {ECO:0000313|EMBL:KFB39114.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC006442-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; ATLV01014585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524975; KFB39114.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VMC0; -.
DR STRING; 74873.A0A084VMC0; -.
DR MEROPS; C67.A01; -.
DR EnsemblMetazoa; ASIC006442-RA; ASIC006442-PA; ASIC006442.
DR VEuPathDB; VectorBase:ASIC006442; -.
DR VEuPathDB; VectorBase:ASIS015301; -.
DR OMA; PIFVLEH; -.
DR OrthoDB; 5397179at2759; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02670; Peptidase_C19N; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR11830; 40S RIBOSOMAL PROTEIN S3A; 1.
DR PANTHER; PTHR11830:SF3; CYLINDROMATOSIS, ISOFORM D; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 276..633
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 33..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 70991 MW; 760F2B2ADC5A93AB CRC64;
MLPEAYDKDL LDGIPTTVLD YFEDFRDDLE RRFTSDEEEE INAPEGYGTS NGGHGASFGG
TAASPLGRVG DNGFDNTIPG SGLLGRIGSI SPESDVGCGS LAPSPLQELP NDPSLGVGSM
VEVTLDPLDA AAGSMHTNGG PGEQLYHGVI RWIGVLPTGG GGGSHRNVMV GVELEEDPNH
PTLELSNGTY AGIRLFKCPA NRAIFVHAGQ CSHDRRFQEM PPMSPSTSRT TQVSSSGSKT
DTTMFGKVDC PVVKGSVPPL KILKLEELKE ICGMFKGIQG HHNSCYLDAT LFAMFTFTSV
FDSLLFRPKE PEDNPQYEEV QRVLLEEIVN PLRKNHFVRA DRVLKLRQLL DQLSSVTGLM
SEEKDPEEFL NSLLAQILRA DPFLKLSSGL DTFYYQLFVE KDERLNLPSV QQLFEQSFLA
SNIKLKEVPS CLIIQMPRFG KNFKMYPRIL PSQVLDVTDI IEDSPRQCCV CGKVADYECR
DCFGKMRNEG LEETAICKNC IDSVHQHNKR VNHKPVPLTV PQDFIPMAPH CEVPRLYMEL
FAVVCIETSH YVAFVKAASG QDAPWCFFDS MADRNGEQNG YNIPKMVPVP DLPHWLTDEG
SRALHEEAVN DKMLPEHAKR LLCDAYMCMY QSTDVMMYR
//
