ID A0A084VZ73_ANOSI Unreviewed; 2089 AA.
AC A0A084VZ73;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Protein-tyrosine-phosphatase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ZHAS_00011049 {ECO:0000313|EMBL:KFB43267.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB43267.1};
RN [1] {ECO:0000313|EMBL:KFB43267.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC011049-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01018616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01018617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525239; KFB43267.1; -; Genomic_DNA.
DR STRING; 74873.A0A084VZ73; -.
DR EnsemblMetazoa; ASIC011049-RA; ASIC011049-PA; ASIC011049.
DR VEuPathDB; VectorBase:ASIC011049; -.
DR VEuPathDB; VectorBase:ASIS012525; -.
DR OMA; QCHQASP; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF527; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7; 1.
DR Pfam; PF00102; Y_phosphatase; 4.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..2089
FT /note="Protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001784249"
FT TRANSMEM 129..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1620..2079
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1910..1933
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 235..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1878..1908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..613
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1894..1908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2089 AA; 222425 MW; 955B9344C4BB79F6 CRC64;
MLYAAPYRRA RRRLLRLLLV VSAVCSADVL ASPTTAYDSY DSEHHAGLVR QGVETASNGR
EYHPLHLQHH HLHHRNALSP AASSIEVGRQ DVQEAAETLP VQQQQYLAHG GGDSVTRVPW
YGLTELSDVL LLAVLVTFAV VGLLLFSVLV LGLRSKLQHF ARSTRQQEQQ EQPDGFLLPD
YADRKKECSS AAKCSVGGSA KLQTKLPAPS LILVETGHVL VRPVPATCVA VTVRDKNSDR
ETAPRGRRRI EQPLSLSDKR HPSSPSAQST TTTTTTEVAT SVAGKRQSPL PIAATLPTAT
MSATTVEPAN TSSQGPTVSN VEGSSANNDK ENCLQQHNSS EHTVEQSQHQ QHPVLPTSQR
NVLKRQPVAE ISLFGPPGTP GPAGSPTTFI QLLTPSSASS LSTSATTTDN NATPTKGAST
GGGASGPVLS AAETMAAARF GFSPRSIHSF TVQTATYFRF PDVDDFTPTP RSMRSAAKHH
EATESSSTPP AVDACTEEEG VVVSTEKAPA VEPPVVKCEL QPASAEAKPA EPAPPEREAR
PAHRICAPMA NRRVRLKSIS LDSEGARLVE ENLTSTIPVQ ELVGMAQQRT TGRFDEDDND
DEDDDEDDDD DDPDGNHRQS RNDNDDGGAG GSSNSKHAKR VRNILNLRLN IPPAGSALTT
APLAPPGASQ STGSMAKAAP RTMVTVSGSI SNPTMSSTNT TTYPPLQHQH HGMMAVLGVG
GAGGQMDESN EQFYFEYYDY GDTDEEDDYD GVDYDEEHED NNNNRMVGEG TVAVSLPSAP
KTPTLSQSKQ KASSLDSDKL RLTTATVPYG GTGNVASGAP GGSVSCSGGI SHILSIAQST
SGHSMSTLSY PSTQHPREQQ SGRQQQQQQQ QHHLHGQQQH AQQQLQQPPR RVSSASVPTT
PKRYQYRSAV NHHYHHTHHQ QQASGQSKLK PSYHPGAAPT THLSMLVGDG GGGGCGEGEP
NRKDKSSVGG HKGTAAGGGT TTTTTTTVAL PPSSSSTTID SMKGGGQQTN EEPGGKSTKD
SVTGKVVPTS GRSSILQRRG SNHSLTLNLD VYTRGGSVDL TSSSCSLYRG SYKNLHQVQS
HTQLYQQYPD AGSTVRVQCH QASPQQQQGG PLSSASAAGT PHANANNNNN ASSKKNLLQR
RGSNTSLTLN LRSGLGTGGA GGGGGGGGAG GVGGSAFGLN RFSSHNSLNM THILLTTHTQ
NEATGGGMML EEDELDCTGA GNGGGEGELR RFGSSMDAGM LHGGGGGGGL GCGSERAGVG
DGSGVQARAG RSANYGRLTV ATMHGTSMDT GSNTSGQQYG GGMMDDTAGR AGASCGARTG
GHHYTVGARQ RKFRSSDSLH NINSVREHAV LGCERHQHGS DAVDSHHQTE AKMMSVSNYQ
RSCQSSFDDR HHFGSSENVK DHQSKLSTHR GLFQRDPATV TSTSSANNLS ALGTGSLCTC
CCCCCCCCCP GGDPMDGGTC CDATGLIVKT GNLSISNSNI RNISTKPLSP QTTSEDFKIY
LANIQFLQNA SNVLTIAYLR KLHNFFSKTY RRMLSSVSGA GQRRPSKEQQ QQQETTEPQG
LSGIDGGPKM MLLHSDSLHH PPVCDDETYD EEHKKMVLKI HQEFWDLPTN YQEKPLVFGS
QAKNRYKTIL PNEHSRVILE AERAVVPSSE PYINANYIKG PDYASNCYIA TQGPLPNTIY
EFWLMVHQNI IRAATASPAS PGSPTGTTAE QAQKIVMLTN FVENGRQKCA VYFPQEEGDW
LAFGSTADVD VSDVLEHKAE LEAAAGERTE NNPTKLRCAS GFFLVHNHCV EQRNGYTVRT
LTVVYGVRKD TAGVAGSAAG SRTESVDHGD DGDEFELTSF RAHHYWFPDW PDHRSPNDIN
VLLDLSLDVL GKDGASLSLT GSEREEPSKE VYATRSCASP NGSASRVPTQ GSAVLPIIHC
SAGIGRTGCL IAILNGLRQL RLSVSAHTKR KQLKRHPQLH PAQICSSLPV AIDDGAEPMP
DGTRNAVEVS GVAITDTEPG DGPLPDDDEL EQRFPLPPVP GGAVEARING RGPQLTGAQR
GESGQVDILG IVCNLRLQRG GMVQNSEQYE LIHRALCLYL EQLTQEGHI
//
