ID A0A084VZI5_ANOSI Unreviewed; 105 AA.
AC A0A084VZI5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Histone H2A {ECO:0000256|RuleBase:RU003767};
GN ORFNames=ZHAS_00011174 {ECO:0000313|EMBL:KFB43379.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB43379.1};
RN [1] {ECO:0000313|EMBL:KFB43379.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC011174-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|RuleBase:RU003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003767}.
CC -!- SIMILARITY: Belongs to the CMC4 family.
CC {ECO:0000256|ARBA:ARBA00009858}.
CC -!- SIMILARITY: Belongs to the histone H2A family.
CC {ECO:0000256|RuleBase:RU003767}.
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DR EMBL; ATLV01018848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01018849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525251; KFB43379.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VZI5; -.
DR STRING; 74873.A0A084VZI5; -.
DR EnsemblMetazoa; ASIC011174-RA; ASIC011174-PA; ASIC011174.
DR VEuPathDB; VectorBase:ASIC011174; -.
DR VEuPathDB; VectorBase:ASIS009261; -.
DR OMA; FACKLQK; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.287.1130; CytochromE C oxidase copper chaperone; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR027179; MTCP1.
DR PANTHER; PTHR15590; CX9C MOTIF-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR15590:SF0; CX9C MOTIF-CONTAINING PROTEIN 4; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR Pfam; PF08991; MTCP1; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47072; Cysteine alpha-hairpin motif; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|RuleBase:RU003767};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR627179-50};
KW DNA-binding {ECO:0000256|RuleBase:RU003767};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU003767}; Nucleus {ECO:0000256|RuleBase:RU003767};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 72..105
FT /note="Histone H2A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16211"
FT DISULFID 10..41
FT /evidence="ECO:0000256|PIRSR:PIRSR627179-50"
FT DISULFID 20..31
FT /evidence="ECO:0000256|PIRSR:PIRSR627179-50"
FT DISULFID 42..52
FT /evidence="ECO:0000256|PIRSR:PIRSR627179-50"
SQ SEQUENCE 105 AA; 11851 MW; 71448D09E85C6FB2 CRC64;
MSKSKPKDPC KVAACRIQTC LKEHDFDEVK CYDVIDDMRQ CCLKWHKVSL CCSGIQLDRD
YKAEKLAIRN DEELNKLLSG VTIAQGGVLP NIQAVLLPKK TEKKA
//
