ID A0A084W1A6_ANOSI Unreviewed; 1745 AA.
AC A0A084W1A6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=AGAP004701-PA-like protein {ECO:0000313|EMBL:KFB44000.1};
GN ORFNames=ZHAS_00011829 {ECO:0000313|EMBL:KFB44000.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB44000.1};
RN [1] {ECO:0000313|EMBL:KFB44000.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC011829-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01019250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525266; KFB44000.1; -; Genomic_DNA.
DR STRING; 74873.A0A084W1A6; -.
DR EnsemblMetazoa; ASIC011829-RA; ASIC011829-PA; ASIC011829.
DR VEuPathDB; VectorBase:ASIC011829; -.
DR VEuPathDB; VectorBase:ASIS013043; -.
DR VEuPathDB; VectorBase:ASIS013410; -.
DR VEuPathDB; VectorBase:ASIS016542; -.
DR OMA; NFGIERF; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032057; DUF4799.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46848; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR PANTHER; PTHR46848:SF1; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF16056; DUF4799; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 574..708
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 849..927
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1027..1210
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 123..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1610..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1745 AA; 190692 MW; E01676344CBB9E18 CRC64;
MLKWTVTKRS EASGGNVLSQ GQVLMQKRRH ARRSLGALSE RIEAAGRNAV SNDGAGNGLA
THHQIKLRRS LGTAVHGVAN YDKENQCITS TPHPMTSSRT LDSPYSTALR DVSNITPNTT
PCRLSTVSTP QSRKRTWATS PASAGQKRAP NQEITVLREP YATTLPTFDI EYSPCGGKNV
PFLAIRGLGM TEFENPGRYF PTDDEEPSSK RCKVSEKQSM SDETAPKKAP VGAPGLTPLS
SRFADLRFNK GSFKRPRSVA KTVNNNHLPP PETGVDAPEE TNELSLNSSE MGDITLDKMI
DAILESAKKD TRWATPRPKR SSSIKSKQSK GSSPTYTPAD DPATDLYLLE RRLPARIAQQ
AGDTTIILEE TSHVNEREVK TPEPIREHQT TSSTRRGFRQ SLNKLVLASP LEAACHLRRQ
KAVRRKHGKQ ESGGHPPEGG GVASIPRKDM QGRGASKSPE TPNVAFSHSR IDQLALIKTP
VHEGVCIFAP EEGTVELQKQ QEQQLVSATA TPSIRSIDLQ GTSTPTESIE KTRKCLNFSP
TLSEDSLEKR GSVASSMTSR CSRAGFVLGT GPTVRGTLEL SIGFDQTGRL QVHVIRCRDL
QRTQTGSTAG CNAINAYVKV ALTNTGNTGS VQAGHTEFGP FQRTAVHRNS SRPIFDHRFF
FDIQPDDERR IQLAVWHRDR ECRRSEFLGC ISFPVQSATK QDINGAYHLQ PQSCLTNPIA
PLPDTMCENS QSSVDEIVCA VDTTSSAMSL SAGVAAGTAP EGAGVTNTAN TDHTNGASEP
LSLSKKALHQ RDADENLFLR FLELDPSPEV APSGGCGNLP VPATPRRNSV CSSTKPASAS
LGRTPFTITK RLARTGDRGF GFSIVWTHPP RVEKVESGLS AEKAGILPGD YVVFVEKHNV
VTMPEQDVLN LIRSQGNTLL LEIFRRPQQA GGQQSRSNGL RNSVTGPANP SVVGSSNAIN
FPPLNACAAI MPSLLDEPSL KTAAPYGVAR SSTACSNFSI ETAKRKLHLP QVTFSKESIV
QPFPDDHRRK FLYQLISREQ HFVNAINFGI ERFVNPLRER KDLISPNDHK TLFQNIDELS
RISEDILEQI IQDDTEPHIH FASRVYLSKS TALCAAYRKY CNGLKKADCV LVNKSRNSNC
DFMKFITEPP VPRKRPDLTT FIHRPLQHFR EILKLVQMIA SHCRVDSEEH NNFNSIISEL
QIAYREITVG GGLMEPIGEG RPLLTLQDLE ARMVFTKCKP FQLASHGRQW IFGGDLSRVE
GRSIKPYWTL LFSDILLFAK VSRDRVLFIT EEPIALSTIT DSCFNIRKKS TEFRITTDPN
GRQIESPTVH CAPDLTRTPK KSSKKRYIVL RAPSTELKAV WQNLLTRQIF LVNATLGSTP
LSSPLDSPDI LQSLVPISDI GATATTMASV KVPSLDSIHL KNQQVCSLGS LAQAPSCHSV
SSASFHNASA TVLSGKGFNG NVGKKLSTLS GRSNTVESRS NRSVTTIQGS ISELPELILL
HQSTNNWAMA GLATSRLHNG PLTKTNEFAN DEINQNYITT SGVNIECENI SCDDLPSSTV
SSADVSNAQR GMVTLSSRDR ILQSFSRGSR DNMRSIVEFS LSSVGRSFID NADDSDPDRQ
STSVAEEYVP TPETPPPNVS PSSSNKVSDT FSNDFKETTT PPSASVSPIA GDAGGQITNA
DCSKYLLASG YGGSWDLLEL DLDFHQVNYD PSFGNDVTET EFLGDDDDPF GMLPTQPTPP
NLLDL
//
