ID A0A084W2W1_ANOSI Unreviewed; 5401 AA.
AC A0A084W2W1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=AGAP005471-PA-like protein {ECO:0000313|EMBL:KFB44555.1};
GN ORFNames=ZHAS_00012435 {ECO:0000313|EMBL:KFB44555.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EnsemblMetazoa:ASIC012435-PA, ECO:0000313|Proteomes:UP000030765};
RN [1] {ECO:0000313|EMBL:KFB44555.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC012435-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; ATLV01019709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525278; KFB44555.1; -; Genomic_DNA.
DR STRING; 74873.A0A084W2W1; -.
DR EnsemblMetazoa; ASIC012435-RA; ASIC012435-PA; ASIC012435.
DR VEuPathDB; VectorBase:ASIC012435; -.
DR VEuPathDB; VectorBase:ASIS002686; -.
DR VEuPathDB; VectorBase:ASIS010562; -.
DR VEuPathDB; VectorBase:ASIS013793; -.
DR VEuPathDB; VectorBase:ASIS015089; -.
DR VEuPathDB; VectorBase:ASIS016338; -.
DR VEuPathDB; VectorBase:ASIS018178; -.
DR VEuPathDB; VectorBase:ASIS021181; -.
DR OMA; FKSESHY; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR CDD; cd13325; PH_unc89; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF22; TWITCHIN-LIKE PROTEIN; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 21.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 21.
DR SMART; SM00408; IGc2; 17.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 21.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 14.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 140..283
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 301..404
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1986..2092
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2107..2194
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2293..2383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2483..2574
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3003..3092
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3102..3199
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3299..3396
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3404..3494
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3501..3590
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3599..3687
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3694..3791
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3797..3885
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3899..3988
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4012..4112
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4366..4620
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 4836..4920
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4932..5026
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5080..5335
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 56..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2843..2874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2886..3003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 634..668
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 792..819
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 990..1028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2912..2994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5401 AA; 608098 MW; 11BD3721101C8BC5 CRC64;
MYDILVVNKN YDAEGPDSIS VRIGDLVEVL DMGDSAANAA KKPKLDPQMN IGQAEDRLDS
SASRHKLAVK PKKNHQSSAH RRSVSPQPPS YQPKPNEKWK VRIFDGDDNA KAGWIPVSVL
DIMHTEQAVF GEKSNDAAYR REAVVRELVE TEEEFAKDLQ QVVDNYLKYI DNKDNKVPRV
VRDHKDDIFN NFKQIADFHN TVLIEGVKYY ANNPKMIGKT FLRLERDFDK HVRYCRDAPI
AQEFLASNDD IRDFFMELLK YSTALGENVL DIQKALELML SVPSRAANNK FLENIEGFRG
NLQKLGRVLA HEYFGVRDKE NKIKERYLFL FKSRILITKV KRLSDDRSIF ILKDIVRLPD
CQLREIDSRA FELQPKAKGD PVHLIAYSEE AKQRWIYEID EYASNAVALQ EHTNDDLRID
PTQTNIDESI IKLPQRIEAH KTDENIKPSD IADSYVVFKH KTSRDESHQA LQKIQYLQQQ
QQQHLPQQIA TGEPAVQGEE EEEKPASVQE RLAAFEVKKS AKKLDLTHTK QEQSSQVTAI
QSSTQVVQSS TQVVQQSESK SVSSTSSVVI KQEQHQQQVQ QEAHRSVAVK RQQEAQLESV
SKSSKVQVES KSISSSSSVS SQSSASFAEV TTETQQTQQQ LIDQQTKIKQ IESKYAALKQ
KQLEQKNDIV DAKFQIVESK FAALKQKQEL LLQEQHQQQV TVVTQQQQQQ QTQQSAVQQI
EAKYAAQKQE ETVSKIQQIE SKYAARKSSL SGPSGDESVK QIETKQITAA NQQSQQQPQQ
QTVVSSPVVE KNQESLSKLQ QLESKYTAHR QQAKEVVKET VDIVQTTTAV EEVKPEAPDS
PQPESLSKIQ QIESKYAALK ARQQQQLQEI KAAEVKTENT TATASSEQAN EEPQSKIAQI
EAKYALKRLQ SLTVDDAVKV QTESKLPVPV KKEEQAPAIK TVESAKTTEA VKVEASKTTT
TTTAVEKQKT EQLSKTSEVY VNENKKLEEA AKKSTEAVKS ADTVKTQEVK VEQVKVADTK
KKIPEPIKLP EQANKTANEK GPDSPKKSKR PKSPKSPSPK KDAATPFKGV EKQKPEEPKK
VEPVKVPEAP KKVEKDVKPV EPAKPVEQPK LVEAAKKAEE KPAVKTEEPK KIPEPAKKVD
VAPKPTTVNI EQVKAPETTK TPEVVKKPEA AKPQEPIKTP EAQRPKTIEA PKAPEPPKKP
AEPAKAAETP KKPVEPPKVP ETPKKPVESA KAPETPKKPA EPAKVSETPK KPVEPAKAPE
TPKKPAEPTK VPETPKKPVE PVKAPETPKK PAEPAKVPET PKKPVESAKA LETPKKPAEP
AKAPETPKKP VEPAKVPEAP KKPVEPAKAL EPPKKPVESA NASEASKKPV EPAKVAEPTP
KLSEKKTDNV KVTEKKTEVL QTTQKAVSES VSKVSTTTTK KGHSTPAAAS EADASVEGVV
EQKSREEALN RKLEEIYARE KAALAEAKRF RELEEQEIRR KFEQRSNREI QQIKETTSEF
LQQIAATRNL VHSVLETSVD PKLPQITKAA ASGGADSNTQ RAQGSDSGSN DQSSNQDTSG
SGEQGAEQGA DQSASGDGNA NEGNGNEGNG DGREDKKRTP PPLQLPTFFD PPPPPVYYAT
IEVFVKKERP PPPPPPKITR KLVVNTDELE RKTQAFFDGE INEPDPDFSI AAAHRKLKGI
KHIYKKADET VLYAEDTITK AEQGEFDSIV IPEPEEDKRP REPAYEYQYT VEDPVTGARV
CTADPNVVLI ERELTMDDQY STTHSRYTSS RLSSRRSHIT EAQEKELAAI ETRHESKMST
TRTKKIRVPT NIRPHFVKPI RGLNVEPGEN AKFSVQVDEL SNMQWLKDNK PLEDRLADRV
ITKENDDLSY TLEIQHCREE DSGIYTARAI NGTESASCTA QLIVETLTPE QRKAMSESNS
PVFSIQLKDT EVIEKTYLTF MVKVKGDPSP KVRFCKDDKE ILDTDKRMKI NRDHADSGFY
ELIIPEVHKG DCGVYSCTAW NKFGTTKTEA QLLVADQLDL FSELDNLDDK TKFVWKKNGA
PFDPEERFKV LMADDSDSLA LVFQHVKPED AGLYTCVAAT ASGNIQCSAE LTVQGQVNQL
IQEPSKPHLE VESKDALARI GGKALLEMKV KGYPKPEIVW RHEGTIIEPG GRYKFLYEDA
ESVSLVIKDV QASDAGAYSI VAQNELGEDS TFINLVVKTP PTITKPHDMS AMVNEQYKMS
IEVNACPAAT VRFFRNGKEI REDDRIKFLT AENYYIIKFN NTVLEDAGNY SIIAMNEISQ
ASEFWEFTIN SPPRTTLGLQ GEAIVNEKED IELIVKAESN PAPIVRWYKD GKEVVADGKR
IIILADDGRY VLKIHAANRD DTALYTADII NDYGTVTEKS QVNVHTKSKV REQLTAVTCK
EGDTNVVLEV RADGFPRPKV QWYIDDVEIT ESRNEYKFQE DGLYYQLVLK EAKAEMQGVY
RARFTNDHGT DETSATTTVQ CSPKVRKPLV DTDVDENTTL TLEVEIYAEP VPEVTWFKNG
QPIQTDARLT IKRDSQRIEN YTLSLTMVRG ADSGDYEVRA VNSMGTATTK GRVVVQMTYL
EEHDDGVQQL VEEEAIVTDT VTFEEEETIL QVQEEAHPAL VQEPEDEVVV PPEQLITVSD
VAEEITLVTE VTIAAPGPAT APIAVPELEP ELHEPPPSPV TRQEPEAPVR IATKEEAIAA
SPGENAEAHR MISECMKIGQ HGETIMVSVC TEESHAAIVT GPEESHSIHQ MRATTVIFEE
DASSPIEVMQ KIIYPNQPHA SAFHVEEIDT ITFVSPEQKR QFLSQASANE STATRTVIEE
IESDNEASIK EQLSRGVSIT SAASEEELYS RQSSRTGVES ETTKPSNATL GESDLTQEQA
IPERIDATQG QPKVDDVPLE QKPQKGNLLE TGTAEDRSRR KSMEKKVSFE DELPQKARML
EKEDVVEKEP DQPEPVEEQI CERKPVESKV LQKEQIEEGT VDGTPKKAAE KGPEQPARPE
ASPEILKTDI ADVTTFDSLP LIWTVEADGI PRPEVSWYHN DELVKASDRI RITDSGTTYK
IENRDVKEAD AGEWKAVVKN RIGEKSLPAK LTVIPCKEYR RPKFMSGLQT ISVHKNEPVT
LSVTLTSDPE PEITWLQNGV EVKADDFVQM KTEVKELEHG LKEFTYTLHI AQARHYDTGD
YTFRAKNKYD INESNGRLDV LLKPEIENFH DTTVLPFTQG VFQVLVKANP KPKVTWTKDG
LNLCNNDNCD VIADIEKEIY TLVIESCALA EHGTYTLTAT NAQGETIANA KLNVQTQKPI
FTKEPDSLTV HDWADVYNKV VVQGVPRPAI QWLHNGTPLD TQQIDEESQE PKIKIVTSGD
AEVTSELFIT HFGPELQGEY SCLATSIGGE TEAKFNIQVK NEQPVFGKGL ERSMDLEEDD
RLELRCIVDG SPLPKMTWYK DSNEITADDH VKITYGHDGI CRLVIDKCLP GDSGCYKLVL
SNKSGDVTTQ CGVAITPKQS PPVFVRPLQD HKLVVGETLH MEAEIVGFPM PEVRWFKDGL
PLRQTRGINF INQPDGLIGF IIDRVTAEDG GIYTCEVKNK NGEAKSASVT EIVPKGKKPQ
FVSELMNVNI VEGFPVKLGV KVIGYPQPAI KWTHNGTLVT GDRYRITDEA EGYVTLALDK
TTGTDCGEYQ AIATNEHGET VSAAAVTILP TTDPSLPEEP PSFLGGLRDI TADEGKELTF
SARFAGNPAP EVIWTKDGEP LQPTGRVTVT CDGKSVGLTI SPAEMSDSGE YACLMANPLG
ETETRATAIV RKVFQKPNFV YPFSDLQQLP GLEAKFPAKL VGVPRPEVQW YKNEDPIYPG
DRFKMKYEGD CCCLYIKECA PEDTGLYSCT ATNREGSSTI EAKLDVVTRI EKRDEPTPPS
FMKKINDLTL LEGMKAKFTV CVDGLPMPTV EWIRDGRRLV PSEKYRIEAE KNGLARLIVD
DVQEEDLGRY SCKAVNNLGE AICHANLKFE PMDFRPRRRY VKGKGKDLLH TPPYPLTERP
MISKLSDRRL TLSWRPSMTT VPRYPVTYQL EMMELPDGEW HTTRSGIRGC SSEVRNLEPF
REYKFRIRVE NLYGVSDPSP YVQTYRQKLE PEPPVFYPYL GPGRDFRPDT SSFYPRDFDV
ERPGHRRQAL APEFLRQEQP VQYGTKNHNV SLFWFVYGYP KPTMTYYFND QVIEAGGRYS
FSYTRNGQAT LFINRMTDRD VGVYEAVATN EHGTVRQRVC LELGEYPRFL QRPEEVFIMG
RRSGRVEAKI TGVPFPDIKW YKDWQPIHES SRIKMIFYEP DTCVLLLTDA IKKDEGLYSI
SARNAIGSIS SSVTVHVEDN EEDYVYNAHH RTPYVRARNK VYQDFYDIGD EIGRGTQGIT
YHATDRSNGR NFAAKIMYGS PDLRPFMFNE VDIMNILNHR KLIRLHDAYD INRSVTLILE
LASGGELVRD NLLKHDYYTE RQIAIYVYQV LLGLEHMHTR GIGHMGLTIK DLLIAHPGSD
NLKICDFGLA RRIEDDKLYT LDYGMPEFVA PEVINRCGVG LGQDMWCVGI ITYILLGGVS
PFMGRNDRET LTRIKEGKWT FVGSVWEFIS TEARDFITRL LVYEEKHRMT IRDALNHSWF
DIIYRRTFEE YQIGTDRLRS YYYHYRDWYT NASCRTWYRR RPLMSCFDHP SRMVYPPGII
FTPEGTPPPM QVDDIPHKRK KWEEYVSKDA HPDFETASFK SESHYQYGPD TYLLQLRDTT
FPCRLREYMK IAKHRSPSLV SDSNYDGSLP IIRERRRFTD VMDEEIDDER RSRITRYGTD
DSVTVTRRLR NEVGTRLGSY AEAEALIECK REGQPPFFRE KPQTISIREG EPNQIICYAV
GVPKPSVTWF RNDMVITDTN RIKVLDDVDG RSVIQFHPAT HNDVGVYKAV ASNRVAKTVA
RCRVVIAVIP DSPDCPDAVA VSDTEVLLRW KQPRSDGHSP VICYSLEQKE HGKVDWVDVA
SNIDHEFFLV HDLRPNTGYQ FRLAAYNRIG WSDRGIATKT ITTLDPGAPK IQITRAMKHL
QQLTESGQQV CPEERTGRLD YSYEKTPLKW TIEGNYSEKY TFMSEMARGR HSIVVKGLEK
ATDKIVVAKI FELGDERAAE AVEREFEMLR TLRHERIAAL LGAFRPKNTS IAALVMEKLQ
GADVLTYLSS RSEYSEQIVA TIINQVLDGL QYLHWRGICH LDLQPDNIVM ASVRQVNVKL
VDFGSAQFVS KLGTNVTRAG WLDFMPPEVL NDEPALPQTD IWAVGCLTYL FLSATSPFRG
QDEAETRANI SFVRYRFENL FKEVTAEATR FLMLIFKRAP NKRPTVEECF DHRWLVHTDF
MTKKRERAIF PGNRLKQISE EYHTMKTNEA TKSETISNFG GQSPRQLLRS NSIQEELLTT
F
//