ID A0A084W2W6_ANOSI Unreviewed; 564 AA.
AC A0A084W2W6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=AGAP005480-PA-like protein {ECO:0000313|EMBL:KFB44560.1};
GN ORFNames=ZHAS_00012440 {ECO:0000313|EMBL:KFB44560.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB44560.1};
RN [1] {ECO:0000313|EMBL:KFB44560.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC012440-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01019713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525278; KFB44560.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084W2W6; -.
DR STRING; 74873.A0A084W2W6; -.
DR EnsemblMetazoa; ASIC012440-RA; ASIC012440-PA; ASIC012440.
DR VEuPathDB; VectorBase:ASIC012440; -.
DR VEuPathDB; VectorBase:ASIS019755; -.
DR OMA; HMMKSHS; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1800.20; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR039970; TF_Grauzone.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23225:SF2; AT09679P-RELATED; 1.
DR PANTHER; PTHR23225; ZINC FINGER PROTEIN; 1.
DR Pfam; PF07776; zf-AD; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00868; zf-AD; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51915; ZAD; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 3..75
FT /note="ZAD"
FT /evidence="ECO:0000259|PROSITE:PS51915"
FT DOMAIN 258..285
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 311..339
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 342..369
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 367..395
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 396..423
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 427..455
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 457..485
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 485..512
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 513..541
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 164..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 5
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 8
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 48
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 51
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
SQ SEQUENCE 564 AA; 65406 MW; 9967DAFAF6D859BA CRC64;
MSEKCRLCLQ SSDSVFATSI HDGQFRAKLE YVFQFPIVAD ETLPKQVCQQ CLSAVSDFHD
YSQQVLANQE QLVVLSKEKG RRYEAMKTEP TNEPSYHRSN AHATIDSQSG VPIKHEPVEN
AKSHCDDLDG SEPFEMVKIE LPNDDDFYDD EIEASFETDI PAKVKRKSAR KAKPVLQDEV
DTDELNSDDE DKDEDFIPKV ESIDGKVTKR RRKILKGGKH AKKGEGTAKE EIASEKSDGE
DLEKQTEDNK RILEFFKFEC ELCSKSLENL ACLQVHYRRH HGTKGYIRCC DKVFYRRFQL
LDHIAAHEGT IKCAICQKSY KSSRYLGLHM MKSHSREEDR PFKCDKCHQS FHKEHLLKAH
QANHLSEKCP ICEKVVSSKY ALKTHVSRMH GSDRNQICDV CGKEFRTKPA MERHINEHLG
VDVVQKVQCH VCQRWFHGKY NLRKHIRFMH TEDGQVFRCD ICQHESPNSR ALLDHKKRVH
VEERFECEFC GKRFKRKLYL REHIASHTGK PLYSCEVCGA TFNSNANCYN HRKSKHPVEW
EARKQAYLEA QRKSPSSDKK PNSL
//
