ID A0A084W3Y6_ANOSI Unreviewed; 581 AA.
AC A0A084W3Y6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 32.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN ORFNames=ZHAS_00012868 {ECO:0000313|EMBL:KFB44930.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB44930.1};
RN [1] {ECO:0000313|EMBL:KFB44930.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC012868-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ATLV01020229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01020230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525296; KFB44930.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084W3Y6; -.
DR STRING; 74873.A0A084W3Y6; -.
DR EnsemblMetazoa; ASIC012868-RA; ASIC012868-PA; ASIC012868.
DR VEuPathDB; VectorBase:ASIC012868; -.
DR VEuPathDB; VectorBase:ASIS010835; -.
DR OMA; GHDVVMC; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..581
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010759948"
FT DOMAIN 43..183
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 206..518
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 359
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 581 AA; 65779 MW; A73FBDEC419360C2 CRC64;
MKAFPWLTWW CLVCIAFFVG SITPTDSYIV DPGPVVKATK GELWPKARKQ VTSDQFSAIK
PGTFQFQSTN YTCDILSKAL ERYQKIVVAI GNNTRRARAS QAFPVRPEIN SVHRTKHRRS
WRSNANFNGY LDVASVSLNA PCETLPHLGM DENYTIVIDD QQAVLSSFSI WGMLRALESF
AQMVVLADDG STLLINATSI DDGPRFSHRG LLVDTSRHFI DTRTLVQILD GMAYNKLNVF
HWHIVDDHSF PYESSTFPEL SKQGAYHPSM VYTQADVAMI VEEARLRGIR VMSEFDTPGH
TRSWGVSHPE LLTECYDQYH GKLGPMDPTR ESTYTFLENL FREVIQVFPD QYVHLGGDEV
GFECWASNPN ILEYMKQNRL YSFEMLEEKF IQRIVDQIDA LNRSSLVWQE VYVNGVRLPN
GTVVHVWTGN RQDLLSRITR DGLPALLSSC WYLDHLSTGG DWRKFYNCDP HDFVGTGAQK
SLVLGGEACM WSEVVNGHNV LPRIFPRVSA TAEKLWSPAA VNNADEAARR LEEHTCRMNH
RGIPAQPRTV QDSAYKDDPA LPTSRPNTID CHGACCTIKS K
//