ID A0A084W5R1_ANOSI Unreviewed; 773 AA.
AC A0A084W5R1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=AGAP008334-PA-like protein {ECO:0000313|EMBL:KFB45555.1};
GN ORFNames=ZHAS_00013579 {ECO:0000313|EMBL:KFB45555.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB45555.1};
RN [1] {ECO:0000313|EMBL:KFB45555.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC013579-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; ATLV01020688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525305; KFB45555.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084W5R1; -.
DR STRING; 74873.A0A084W5R1; -.
DR EnsemblMetazoa; ASIC013579-RA; ASIC013579-PA; ASIC013579.
DR VEuPathDB; VectorBase:ASIC013579; -.
DR VEuPathDB; VectorBase:ASIS003056; -.
DR OMA; SYGLKMD; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR CDD; cd07072; NR_LBD_DHR38_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF4; NUCLEAR HORMONE RECEPTOR HR38-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 436..511
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 535..770
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..255
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 83812 MW; 95D3B04BF1E2CE5E CRC64;
MKQKQRAETS HRPKCRYGNF PPNRTPKDLA IKNGPVSGDS ADQTQHSNSS SDTLVGLEDT
PSTFGGSSDS IPTAILKASY KEELPSPFSA GPSTRAPTTE PPDTDLLFES SSTEELGLLS
LRSSSDPVLA SSARIPQALV QATAAQQQQQ QQQQQHQQQQ QQIPSLQVQC PDPSGQQLVG
GGSAASAGLP SFQETYPIKY NQLASYGLKM DDDCFKMATS PHHHQAVTAA YAHHGNVYGH
GHQHHNPHHH HHHGGVGGGV GTIGVATGLH QGHYELSPHS GGPGGGGGGG GGITQYNNPT
PGPQAGATGG SFYSPSYEQH PANYGGQVTT QDTYSLPPFP TVAELNVATT CHRRSSLPVQ
RSESTSSSES PKPPRIAIYT KYSALPSASS SASSSPGYMN NNNPNTINNN EVAAVAGSGG
SGGCWSNSVL WSQSASQLCA VCGDTAACQH YGVRTCEGCK GFFKRTVQKG SKYVCLADKA
CPVDKRRRNR CQFCRFQKCL AVGMVKEVVR TDSLKGRRGR LPSKPKSPQE SPPSPPVSMI
TALVRAHVDT TPDLASLDYS QYLEPGQNEP LISEAEKVQQ FYNLLTTSVD VIKHFADKLP
GYNDLSVEDQ ELLFQSASLE LFVLRLSYRA RIDDTKMTFC NGIVLHRHQC LRSFGDWLNA
ILEFSKSLHT MQIDISAFAC LCALTLVTER HGLREPKKVE QLQMKIIGSL RDHVTYNSEA
QRKPHYFSRL LGKLPELRSL SVQGLQRIFY LKLEDLVPAP PLIEKMFLAS LPF
//
