ID A0A084W684_ANOSI Unreviewed; 726 AA.
AC A0A084W684;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=AGAP006888-PA-like protein {ECO:0000313|EMBL:KFB45728.1};
GN ORFNames=ZHAS_00013676 {ECO:0000313|EMBL:KFB45728.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB45728.1};
RN [1] {ECO:0000313|EMBL:KFB45728.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC013676-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01020759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01020760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525307; KFB45728.1; -; Genomic_DNA.
DR STRING; 74873.A0A084W684; -.
DR EnsemblMetazoa; ASIC013676-RA; ASIC013676-PA; ASIC013676.
DR VEuPathDB; VectorBase:ASIC013676; -.
DR VEuPathDB; VectorBase:ASIS014414; -.
DR OMA; DPNYYHE; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd08833; ArfGap_GIT; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF3; ARF GTPASE-ACTIVATING PROTEIN GIT; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..126
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 169..201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 509..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 512..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 78973 MW; AA155692FCBAE30F CRC64;
MSRAKSRIQT DVCGDCGGAD PSWASINRGI LLCADCCSIH RSLGRHISQV KSLRQGSWQV
SVLNFVNQLN AHGANSVWEH LLLDSVSPKN LKRKPTPKDA VHPTKADFIR AKHVNLAYVL
KPSFQVEEGS SLELELSKQL HASVRAGNLE TSLRLLVQGA DPNFFHEDKG STPLHVAVKS
GQLSQIELLL VYGADVTAHD AQGNSPLELA RQAKNSVIAE RLLEAMYEVT DRLTFFLIGK
KPNHAAGQHL LIPDQSKKEM SEQLKIARGK LQLVPNRMFE ELVMDLYDEV DRRETEAIWA
TSALNPESGA VPFLPTNPHL SATRNQGRQK LARFSQPEFA GLLMDVLLDA HRRQNMANLR
PIDGPLPAGL AQLKVSSMPG ARDSNLSDDE PLYDAVASDD DYAALAPVAQ QALVNKSSPA
AVSNVEVETL RQRIQDQELT INELRSMIHR LASENSQLKS HFDAKDPEVQ LGDGKFSGCC
DRIPSNDTNG SGSGSGGCGS CGLRKTPVSM YETRQAPRSD ESRPPITQSL YSMAPAPTAG
ASDTMMSHNV GPDGSSPGGG GQMPPFEEVK HRTDVVARRI KELFAAMKDL AQREAFIPCA
ERIRLAVVDL MSLFPGSLIA NDSIRGALQQ LNYHANLIQA ECARLQQXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXQL NGGGSPGGAQ GKGLGESIQQ SMEQVRGCAY ELAMSTKILI
THVQQS
//
